Method for decreasing low density lipoprotein

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

Reexamination Certificate

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Reexamination Certificate

active

06841547

ABSTRACT:
The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.

REFERENCES:
patent: 20030181371 (2003-09-01), Hunter et al.
patent: WO 02089843 (2002-11-01), None
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Korpela, J.T., et al., “Effect of Oxytetracycline on Bacterial Intestinal Metabolism of Neutral Sterols and on Serum Lipids”,Scand J. Gastroenterol1984, 19:401-404.
Pigatto, P.D., et al., “Isotretinoin versus Minocycline in Cystic Acne: A Study of Lipid Metabolism”,Dermatologica1986, 172:154-159.
Ridker, P.M., et al., “Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events”,N. Engl. J. Med. 2002, 347(20):1557-1565.
Samuel, Paul, et al., “Effect of Neomycin and Other Antibiotics on Serum Cholesterol Levels and on 7α-Dehydroxylation of Bile Acids by the Fecal Bacterial Flora in Man”,Circulation Research1973, vol. XXXIII:393-402.
Shaddad, Sania A.I., et al., “The Effect of Oxytetracycline on Growth and Lipid Metabolism in Poultry”,Comp. Biochem. Physiol. 1985, 80C(2):375-380.

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