Method for controlling protein crystallization

Adhesive bonding and miscellaneous chemical manufacture – Delaminating processes adapted for specified product – Delaminating in preparation for post processing recycling step

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Details

156621, 156622, 422245, 23295R, C30B 702

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active

052562417

ABSTRACT:
A method for controlling the crystallization of protein by solvent evaporation including placing a drop of protein solution between and in contact with a pair of parallel plates and driving one of the plates toward and away from the other plate in a controlled manner to adjust the spacing between the plates. The drop of solution forms a liquid cylinder having a height dependent upon the plate spacing thereby effecting the surface area available for solvent evaporation. When the spacing is close, evaporation is slow. Evaporation is increased by increasing the spacing between the plates until the breaking point of the liquid cylinder. One plate is mounted upon a fixed post while the other plate is carried by a receptacle movable relative to the post and driven by a belt driven screw drive. The temperature and humidity of the drop of protein solution are controlled by sealing the drop within the receptacle and mounting a heater and dessicant within the receptacle.

REFERENCES:
patent: 4886646 (1989-12-01), Carter et al.
patent: 4919899 (1990-04-01), Herrmann et al.
patent: 5009861 (1991-04-01), Plaas-Link
patent: 5104478 (1992-04-01), Sikdar et al.
patent: 5106592 (1992-04-01), Stapelmann et al.
patent: 5139611 (1992-08-01), Pusey et al.
patent: 5190613 (1993-03-01), Yamagata

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