Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer
Reexamination Certificate
2005-10-17
2010-12-14
Sines, Brian J (Department: 1797)
Chemistry: analytical and immunological testing
Including sample preparation
Volumetric liquid transfer
C422S068100, C422S081000, C422S082010, C422S105000, C422S105000, C422S105000, C436S043000, C436S174000
Reexamination Certificate
active
07851227
ABSTRACT:
Especially in order to carry out the so-called enzyme-coupled DNA hybridization test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
REFERENCES:
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patent: 4963498 (1990-10-01), Hillman et al.
patent: 5482862 (1996-01-01), LaPack et al.
patent: 5695720 (1997-12-01), Wade et al.
patent: WO 02/072262 (2002-09-01), None
patent: WO 02/073153 (2002-09-01), None
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Barlag Heike
Birkle Siegfried
Gumbrecht Walter
Kühn Daniela
Paulicka Peter
Harness & Dickey & Pierce P.L.C.
Siemens Aktiengesellschaft
Sines Brian J
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