Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-23
2006-05-23
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007200, C435S007210, C435S320100, C536S023100, C536S023400
Reexamination Certificate
active
07049076
ABSTRACT:
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
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Axel Richard
Barnea Gilad
Lee Kevin J.
Strapps Walter
Fulbright & Jaworski LLP
Guzo David
Joike Michele K.
Sentigen Biosciences, Inc.
The Trustees of Columbia University of the City of New York
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