Method and kit for detection of thrombin receptor activation of

Details Method and kit for detection of thrombin receptor activation of Method and kit for detection of thrombin receptor activation of

1996-06-06

1998-11-24

Walsh, Stephen

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 13, 530300, 530327, 5303871, 436518, G01N 3353, G01N 33543, C07K 700, C07K 1628

Patent

active

058404996

ABSTRACT:
Method for detecting thrombin-induced cell activation via a system of detection capable of determining the presence of the cleaved peptide fragment of the thrombin receptor are provided. These methods are used in diagnosing and treating a pre-thrombotic state or thrombotic disorder in a patient. Detection kits to be used with this method are also provided.

REFERENCES:
patent: 5256766 (1993-10-01), Coughlin
Brass, L.F., et al. "Studies Using Monoclonal Antibodies Directed Against A Defined Domain Within The Receptor N Terminus", J. Biol. Chem. (1992) 267:13795-13798.
Scarborough R.M., et al. "Tethered Ligand Agonist Peptides", J. Biol. Chem. (1992) 267:13146-13149.
Vassallo, R.R. Jr., et al. "Structure-Function Relationships in the Activation of Platelet Thrombin Receptors by Receptor-derived Peptides", J. Biol. Chem. (1992) 267:6081-6085.
Vu, T. et al., "Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation", Cell (1991) 64:1057-1068.
Vu, T. et al., "Domains Specifying Thrombin-receptor Interaction", Nature (1991) 353:674-677.
Gosling et al. (1990) Clin. Chem. 36:1408-1427.
Norton et al. (1993) Blood 82:2125-2136.

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