Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-26
1995-03-21
Henley, III, Raymond J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514399, 514411, 514597, 514620, 514651, A61K 31415, A61K 3140, A61K 3117, A61K 31165
Patent
active
053995813
ABSTRACT:
A method and compositions is described for treating sexual impotence with an oral drug regimen amenable to once a day therapy. The method combines the administration of a non-selective alpha.sub.1 -alpha.sub.2 adrenergic blocking drug, such as dibenzyline, with that of a particular type of beta adrenergic blocking agent which also possesses vasodilator activity, such as labetalol, celiprolol, or carvedilol. The net effect is a reciprocally balanced autonomic blockade in which the reactive beta adrenergic activity induced by pure alpha blockade is blocked by the beta-blockade while the unopposed or reactive alpha adrenergic tone consequent to pure beta blocker therapy is blocked by the alpha blocker. Accordingly, while each drug given by itself, either the alpha adrenergic blocker or the vasodilating beta adrenergic blocker, produces no benefit or at times some small benefit, the combined therapy works for restoring or enabling sexual function.
REFERENCES:
patent: 4801587 (1989-01-01), Voss et al.
patent: 4840952 (1989-06-01), Gamble et al.
Gwinup, G., Annals of Internal Medicine, pp. 162-163 (Jul. 1988).
Henley III Raymond J.
Pabst Patrea L.
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