Method and assay for HTLV

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 71, 435 792, 530324, C12Q 170, C12Q 168, G01N 3353, C07K 1415

Patent

active

056437145

ABSTRACT:
Novel HTLV-I and HTLV-II peptides are disclosed for use in diagnostic assays for detecting and confirming HTLV-I and HTLV-II infection in human sera. The peptides are derived from analogous regions of HTLV-I and HTLV-II gp21 envelope protein, and are diagnostic of HTLV-I or HTLV-II infection. The invention also includes an assay kit and method for detecting, and discriminating between, HTLV-I and HTLV-II infection in humans.

REFERENCES:
patent: 4446122 (1984-05-01), Chu et al.
patent: 4588681 (1986-05-01), Sawada et al.
patent: 4645738 (1987-02-01), Knowles et al.
patent: 4661445 (1987-04-01), Saxinger et al.
patent: 4663436 (1987-05-01), Elder et al.
patent: 4689398 (1987-08-01), Wu et al.
patent: 4722888 (1988-02-01), Broder et al.
patent: 4724258 (1988-02-01), Yoshida et al.
patent: 4731326 (1988-03-01), Thompson et al.
patent: 4735896 (1988-04-01), Wang et al.
patent: 4757000 (1988-07-01), Tohmatsu et al.
patent: 5003043 (1991-03-01), Akita et al.
patent: 5017687 (1991-05-01), Vahlne et al.
patent: 5039604 (1991-08-01), Papsidero
patent: 5066579 (1991-11-01), Reyes
Copeland et al., J. Immunol 137(9):2945-51.
Kurtu et al., J. Immunol 143(6):2024-2030. 1989.
Ehrlich et al, Virology 186(2):619-27. 1992.
Lipka et al, J. Infect Dis. 165(2):268-72. 1992.
Shah et al, Peptide Research 5(4):241-244. 1992.
Hoal et al, PNAS 88(13):5754-8. 1991.
Viscidi et al, J. Aqu. Imm. Def. Synd. 4(12):1190-8. 1991.
Blumberg et al, J. Aqu. Imm. Def. Synd. 5(3):294-302. 1992.
Palker et al, J. Immunol. 142(3):971-8. 1989.
Nakamura et al, J. Neuroimmunol 35(1-3):167-77. 1991.
Horal, P., et al., "Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides" Proc. Nat. Acad. Sci. USA, 88(13):5754-8 (1991).
Anderson, D.W., et al., "Serological Confirmation of Human T-Lymphotropic Virus Type I Infection in Healthy Blood and Plasma Donors," Blood 74(7): 2585-2591 (1989).
Blattner, W.A., et al., "The Human Type-C Retrovirus, HTLV, in Black From the Caribbean Region, and Relationship to Adult T-Cell Leukemia/Lymphoma," Int. J. Cancer 30: 257-264 (1982).
Blattner, W.A., et al., "Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia," JAMA 250(8): 1074-1080 (1983).
Blayney, D.W., et al., "The Human T-Cell Leukemia-Lymphoma Virus in the Southeastern United States," JAMA 250(8): 1048-1052 (1983).
Catovsky, D., et al., "Adult T-Cell Lymphoma-Leukaemia in Blacks from the West Indies," Lancet, Apr. 20, 1982: 639-643 (1982).
Chen, Y-M.A., et al., "Antibody Reactivity to Different Regions of Human T-Cell Leukemia Virus Type 1 gp61 in Infected People," J. Virology 63(11): 4952-4957 (1989).
Chiba, J., et al., "Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus," Proc. Natl. Acad. Sci. USA 88: 4641-4645 (1991).
Cainciolo, G.J., et al., "Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins," Science 230: 453-455 (1985).
Clapham, P., et al., "Pseudotypes of human T-cell leukemia virus types 1 and 2: Neutralization by patients' sera," Proc. Natl. Acad. Sci. USA 81: 2886-2889 (1984).
Essex, M., et al., "Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs," Science (Sep.): 1061-1064 (1983).
Gallo, R.C., et al., "Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma," Proc. Natl. Acad. Sci. USA 79: 5680-5683 (1982).
Gallo, R.C., et al., "Association of the Human Type C Retrovirus with a Subset of Adult T-Cell Cancers," Cancer Res. 43: 3892-3899 (1983).
Halbert, S.P., et al., "Quantitative Estimation by a Standardized Enzyme-Linked Immunosorbent Assay of Human T-Cell Lymphotropic Virus Type I Antibodies in Adult T-Cell Leukemia and Acquired Immune Deficiency Syndrome," J. Clin. Microbiol. 23(2): 212-216 (1986).
Hattori, S., et al., "Identification of gag and env Gene Products of Human T-Cell Leukemia Virus (HTLV)," Virology 136: 338-347 (1984).
Itamura, S., et al., "Expression of the gag gene of human T-cell leukemia virus type I in Escherichia coli and its diagnostic use," Gene 38: 57-64 (1985).
Iwatsuki, K., et al., "Production of Monoclonal Antibodies to Human T-cell Lymphotropic Virus Type 1 (HTLV-1) and Studies of Their Specificity," Jpn. J. Dermatol. 99: 1059-1065 (1989).
Kiyokawa, T., et al., "Envelope proteins of human T-cell leukemia virus: Expression in Escherichia coli and its application to studies of env gene functions," Proc. Natl. Acad. Sci. USA 81: 6202-6206 (1984).
Kline, R.L., et al., "Evaluation of enzyme immunoassays for antibody to human T-lymphotropic viruses type I/II," Lancet 337: 30-33 (1991).
Lal, R.B., et al., "Serologic Discrimination of Human T Cell Lymphotropic Virus Infection by Using a Synthetic Peptide-Based Enzyme Immunoassay," J. Infect. Dis. 163: 41-46 (1991).
Lee, T.H., et al., "Human T-cell leukemia virus-associated membrane antigens: Identity of the major antigens recognized after virus infection," Proc. Natl. Acad. Sci. USA 81: 3856-3860 (1984).
Lillehoj, E.P., et al., "Development and Evaluation of a Human T-Cell Leukemia Virus Type I Serologic Confirmatory Assay Incorporation a Recombinant Envelope Polypeptide," J. Clin. Microbiol. 28(12): 2653-2658 (1990).
Matsushita, S,. et al., "Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I," Proc. Natl. Acad. Sci. USA 83: 2672-2676 (1986).
Newman, M.J., et al., "Serological Characterization of Human T-Cell Leukemia (Lymphotropic) Virus, Type I (HTLV-I) Small Envelope Protein," Virology 150: 106-116 (1986).
Nyunoya, H., et al., "Expression of HTLV-I Envelope Protein Fused to Hydrophobic Amino-Terminal Peptide of Baculovirus Polyhedrin in Insect Cells and its Application for Serological Assays," AIDS Res. H. Retroviruses 6(11): 1311-1321 (1990).
Oroszlan, S., and T.D. Copeland, "Primary Structure and Processing of gag and env Gene Products of Human T-Cell Leukemia Viruses HTLV-I.sub.CR and HTLV-I.sub.ATK," Current Topics in Microbiol. and Immunol. 115: 221-233 (1985).
Palker, T.J., et al. "Mapping of Immunogenic Regions of Human T Cell Leukemia Virus Type I (HTLV-I) gp46 and gp21 Envelope Glycoproteins with Env-Encoded Synthetic Peptides and a Monoclonal Antibody to gp46," J. Immunol. 142: 971-978 (1989).
Patarca, R., and W.A. Haseltine, "Sequence similarity among retroviruses--erratum," Nature 309: 728 (1984).
Poiesz, B.J., et al., "Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma," Proc. Natl. Acad. Sci. USA 77: 7415-7419 (1980).
Poiesz, B.J., et al., "Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukaemia," Nature 294: 268-271 (1981).
Ralston, S., et al., "Identification and Synthesis of the Epitope for a Human Monoclonal Antibody Which Can Neutralize Human T-cell Leukemia/Lymphotropic Virus Type I," J. Biol. Chem. 264(28): 16343-16346 (1989).
Robert-Guroff, M., et al., "Detection of the Human T Cell Lymphoma Virus p19 in Cells of Some Patients With Cutaneous T Cell Lymphoma and Leukemia Using a Monoclonal Antibody," J. Exper. Med. 154: 1957-1964 (1981).
Robert-Guroff, M., et al., "Evidence for Human T Cell Lymphoma-Leukemia Virus Infection of Family Members of Human T Cell Lymphoma-Leukemia Virus Positive T Cell Leukemia-Lymphoma Patients," J. Exper. Med. 157: 248-258 (1983).
Robert-Guroff, M., and E. Shepard, "A Monoclonal Antibody Specific for a 52,000-Molecular-Weight Human T-Cell Leukemia Virus-Associated Glycoprotein Expressed by Infected Cells," J. Virology 53(1): 214-220 (1985).
Samuel, K.P., et al., "Diagnostic Potential for Human Malignancies of Bacterially Produced HTLV-I Envelope Protein," Science 236: 1094-1097 (1984).
Saxinger, W., et al., "Human T-Cell Leukemia Virus (HTLV-I) Antibodies in Africa," Science (Sep. 28): 1473-1476 (1984).
Schupbach, J., et al., "Antigens on HTLV-Infected Cells Recognized

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and assay for HTLV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and assay for HTLV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and assay for HTLV will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-595655

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.