Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1988-12-21
1991-08-27
Naff, David M.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
210634, 264 13, 422255, 422280, 422281, 424409, 424489, 435174, 435177, 435180, 435182, 435287, 435288, 435311, 435313, C12N 700, C12N 1102, C12M 100, A61K 914
Patent
active
050432800
ABSTRACT:
A sterile product containing a substance embedded in a carrier is produced by use of a supercritical gas. In one embodiment, a mixture is formed of a substance, carrier and supercritical gas such as nitrous oxide or carbon dioxide, and the supercritical gas is separated from the substance and carrier to obtain the product. In another embodiment, the supercritical gas contains the substance, and is mixed with an atomized organic solvent containing the carrier to form a mixture. The supercritical gas extracts the solvent, and is separated from the substance and carrier to produce the product. Alternatively, the carrier can be in the supercritical gas and the substance in the solvent, or both the substance and carrier can be in the solvent. Atomization and formation of the mixture can be carried out by feeding the supercritical gas and solvent through a nozzle into a spray tower or column. The supercritical gas containing the solvent is separated to obtain the product in the form of a dry powder containing spheres of the carrier having the substance embedded therein. The carrier can be polymers, lipids, lecithins or waxes, and the substance can be medicines, toxins, viruses, diagnostic materials, herbicides, insecticides or pesticides. An apparatus for carrying out the method contains a spray tower and other means for performing the method steps.
REFERENCES:
patent: 3773919 (1974-11-01), Boswell, Jr. et al.
patent: 4489055 (1984-12-01), Couvreur et al.
patent: 4820537 (1989-04-01), Katz
patent: 4824570 (1989-04-01), Bethuel et al.
patent: 4828702 (1989-05-01), Coenen et al.
Benitz et al., Journal of Pharmaceutical Sciences, vol. 73, No. 12, 1984, pp. 1721-1723.
T. R. Tice et al. "Preparation of Injectable Controlled-Release Microcapsules . . . Evaporation Process", Journal of Controlled Release 2 (1985) 343-352.
L. M. Sanders et al. "Controlled Delivery of an LHRH Analogue . . . Microspheres", Journal of Controlled Release 2 (1985) 187-195.
Franz P. Schmitz, "Chromatography with Sub- and Supercritical Eluents--Influence of the Separation Conditions . . . Number and Resolution", Journal of Chromatography, 356 (1986) 261-269.
L. M. Sanders et al. "Prolonged Controlled-Release of Nafarelin, A Luteinizing Hormone-Releasing Hormone Analog, . . . Weight of Polymer", Journal of Pharmaceutical Sciences, vol. 75, No. 4, Apr. 1986--356-360.
J. P. Benoit et al. "A Physicochemical Study of the Morphology of Progesterone-Loaded Poly (D.L-lactide) Microspheres", International Journal of Pharmaceutics, 29 (1986) 95-102.
G. Birrenbach et al. "Polymerized Micelles and Their Use as Adjuvants in Immunology", vol. 65, No. 12, Dec. 1976, 1763-1766.
A. D. Schwope et al. "Lactic/Glycolic Acid Polymers as Narcotic Antagonist Delivery Systems", Life Sciences, vol. 17, pp. 1877-1886.
D. L. Wise et al. "Sustained Release of an Antimalarial Drug Using a Copolymer of Glycolic/Lactic Acid", Life Sciences, vol. 19, pp. 867-874, 1976.
Fischer Wilfried
Muller Bernd W.
Naff David M.
Schwarz Pharma AG
LandOfFree
Method and apparatus for the manufacture of a product having a s does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for the manufacture of a product having a s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for the manufacture of a product having a s will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1413842