Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Patent
1997-08-14
2000-09-05
Hoff, Marc S.
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
702 30, G01J 328
Patent
active
061156736
ABSTRACT:
One or more basis sets are applied to a spectroscopic signal during analysis to produce an accurate spectral representation from which analyte concentration may be accurately determined. A basis set includes all interfering components found in a sample, such as serum. With regard to an analyte, such as glucose, it is necessary to define those components of a sample that have a larger interference than that of glucose. A basis set may be generated, for example, that produces a transform for the red blood cells that interfere or scatter the light; and also for skin effects. Once the spectra of all these components is known, it is then necessary to determine how each of these components interact, e.g. taking serum data, extracting each of the components, and then comparing the spectra for the individual components with that of the components in solution. The invention characterizes each component in a sample, as well as all other possible interferants and, after producing an accurate representation of each component at each frequency of interest, identifies and subtracts each interferant from the spectra produced at the frequency of interest. The basis sets may take the form of transforms that may be stored in a look-up table for use during analysis.
REFERENCES:
patent: 4893253 (1990-01-01), Lodder
patent: 5308982 (1994-05-01), Ivaldi et al.
patent: 5348002 (1994-09-01), Caro
patent: 5518694 (1996-05-01), Bentsen
patent: 5606164 (1997-02-01), Price et al.
patent: 5655530 (1997-08-01), Messerschmidt
patent: 5743262 (1998-04-01), Lepper, Jr. et al.
patent: 5747806 (1998-05-01), Khalil et al.
patent: 5823951 (1998-10-01), Messerschmidt
patent: 5830132 (1998-11-01), Robinson
patent: 5876121 (1999-03-01), Burns et al.
Arnold et al., "Determination of Physiological Levels of Glucose in an Aqueous Matrix with Digitally Filtered Fourier Transform Near-Infrared Spectra," Anal. Chem., 1990, 62.
Arnold et al., Ohio University, spectroscopic-based glucose sensors no date.
Small et al., "Strategies for Coupling Digital Filtering with Partial Least-Squares Regression: Application to the Determination of Glucose in Plasma by Fourier Transform Near-Infrared Spectroscopy," Anal. Chem., 1993, 65.
Hazen et al., "Temperature-Insensitive Near-Infrared Spectroscopic Measurement of Glucose in Aqueous Solutions," Applied Spectroscopy, vol. 48, No. 4, 1994.
Hazen, "Glucose Determination in Biological Matrices Using Near-Infrared Spectroscopy," University of Iowa Thesis, Aug. 1995.
Hazen Kevin H.
Malin Stephen F.
Glenn Michael A.
Hoff Marc S.
Instrumentation Metrics, Inc.
Miller Craig Steven
LandOfFree
Method and apparatus for generating basis sets for use in spectr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for generating basis sets for use in spectr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for generating basis sets for use in spectr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2222490