Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Enzyme inactivation by chemical treatment
Patent
1997-09-08
1999-07-20
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Enzyme inactivation by chemical treatment
435180, 435183, 435213, 514184, C12N 1108, C12N 976, C12N 999
Patent
active
059255536
ABSTRACT:
Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
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Clark James M.
Jenkins Thomas E.
Katz Bradley A.
Stroud Robert M.
AxyS Pharmaceuticals, Inc.
Lilling Herbert J.
The Regents of the University of California
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