Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi

Details Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi

1995-06-07

1999-03-09

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514454, 514716, 514717, 514718, 514721, 514728, 514731, 514732, 514734, A61K 3138, A61K 3135

Patent

active

058801464

ABSTRACT:
Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.

REFERENCES:
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Correale et al. (1995), "Patterns of Cytokine Secretion by Autoreactive Proteolipid Protein-Specific T Cell Clones During the Course of Multiple Sclerosis," 154 The Journal of Immunology, 2959-2968.
Germann et al. (1995), "Administration of Interleukin 12 in Combination with Type II Collagen Induces Severe Arthritis in DBA/1 Mice," 92 Proc. Natl. Acad. Sci. USA; 4823-4827.
Article Abstract (1993), "Interferon Beta-1b is Effective in Relapsing-Remitting Multiple Scherosis. I. Clinical Results of a Multicenter, Randomized, Double-Blind, Placebo-controlled Trial," 43 Neurology; 655-661.
Mosmann et al. (1989), "TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties," 7 Ann. Rev. Immunol.; 145-173.

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