Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP in

Details Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP in Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP in

1997-12-18

1999-11-30

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

514247, 514256, 514357, 514365, 514378, 514439, 514471, 514513, 514532, 514534, 514570, 544335, 546340, 546342, 548204, 548240, 548247, 549 76, 549553, 558254, 558255, 560 16, 560147, 560153, 562426, 562556, 562557, C07D27724, C07D27726, A61K 3110, A61K 3805, C07C32732, C07C32341

Patent

active

059945397

ABSTRACT:
Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described.
The compounds of formula I are endowed with a mixed ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.

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