Measurement of platelet activities

Details Measurement of platelet activities Measurement of platelet activities

1992-06-03

1993-11-30

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 26, 435 25, 514570, 530308, 530381, 436 69, 436 63, C12Q 156, C12Q 132, G01N 3386, A01N 3710

Patent

active

052664627

ABSTRACT:
Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.

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patent: 4880788 (1989-11-01), Moake et al.
patent: 4900679 (1990-02-01), Spillert et al.
patent: 5017556 (1991-05-01), O'Brien et al.
patent: 5066787 (1991-11-01), Reutelingsperger
patent: 5066788 (1991-11-01), Reutelingsperger
patent: 5120537 (1992-06-01), Esmon et al.
Abstract, Proc Natl Acad Sci USA Feb. 1984, 81 (3) pp. 913-917.

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