MCH antagonists for the treatment of obesity

Details MCH antagonists for the treatment of obesity MCH antagonists for the treatment of obesity

2008-03-25

2008-03-25

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S063000, C544S224000

Reexamination Certificate

active

10308782

ABSTRACT:
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

REFERENCES:
patent: 5908830 (1999-06-01), Smith et al.
patent: 0507291 (1992-10-01), None
patent: 0955293 (1999-11-01), None
patent: WO99/64394 (1999-12-01), None
patent: WO01/85714 (2001-11-01), None
P. Grammaticakis: “Contribution à l'étude spectrale de quelques derives de l'isocyanate de phyényle. I. Absorption dans l'ultra-violet moyen des derives phénylcarbamyleés de quelques amines, hydroxylamines, phénylhydrazines, cétimines et oximes”Bull. Chim. Soc. Fr.Paragraph C, 667 (1947).
Shimada, et al., “Mice lacking melanin-concentrating hormone are hypophagic and lean”Nature396:670-674(1998).
Borowsky, et al., “Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist”Nature Medicine8:825-830(2002).
PCT International Search Report dated Mar. 10, 2003 for corresponding PCT Application No. PCT/US02/38408.

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