Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-11-22
2000-03-14
Stockton, Laura L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
514342, 514352, 544159, 544160, 544168, 546 23, 546309, 546329, 546335, 548495, 558416, 558422, 560 19, 560 39, 560 42, 562430, 562442, 562451, 562450, 564153, C07D21372, C07D41712
Patent
active
060374721
ABSTRACT:
Compounds of formula (I) ##STR1## and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviated by the inhibition of such matrix metalloproteases.
REFERENCES:
patent: 4558034 (1985-12-01), Galardy et al.
patent: 4576941 (1986-03-01), Suh et al.
patent: 4696939 (1987-09-01), Suh et al.
patent: 4801609 (1989-01-01), Haslanger et al.
patent: 4885283 (1989-12-01), Broadhurst et al.
patent: 4996358 (1991-02-01), Handa et al.
patent: 5006651 (1991-04-01), Broadhurst et al.
patent: 5114953 (1992-05-01), Galardy et al.
patent: 5124322 (1992-06-01), Hughes
patent: 5183900 (1993-02-01), Galardy et al.
patent: 5189178 (1993-02-01), Galardy et al.
patent: 5190937 (1993-03-01), Markwell et al.
patent: 5268384 (1993-12-01), Galardy
patent: 5304604 (1994-04-01), Davidson et al.
patent: 5696147 (1997-12-01), Galardy
patent: 5773438 (1998-06-01), Levy et al.
Chapman, et al., J. Med. Chem (1993), "Inhibition of Matrix Metalloproteinases by N-Carboxyalkyl Peptides", vol. 36, pp. 4293-4301.
Lohmander, L.S., et al., Arthritis and Rheumatism (1993), "Metalloproteinases, Tissue Inhibitor, and Proteoglycan Fragments in Knee Synovial Fluid in Human Osteoarthritis", vol. 36, No. 2, pp. 181-189.
Rodgers, W.H., et al., Am J Obstet Gynecol (1993), "Expression and Localization of Matrilysin, a Matrix Metalloproteinase, in Human Endometrium During the Reproductive Cycle", vol. 168, pp. 253-260.
Sires, U.I., et al., The Journal of Biological Chemistry (1993), "Degradation of Entacin by Matrix Metalloproteinases", vol. 268, No. 3, pp. 2069-2074.
Busiek, D.F., et al., The Journal of Biological Chemistry (1992), The Matrix Metalloprotease Matrilysin (PUMP) Is Expressed in Developing Human Mononuclear Phagocytes, vol. 267, No. 13, pp. 9087-9092.
Crabbe, T., et al., Biochemistry (1992), "Biochemical Characterization of Matrilysin. Activation Conforms to the Stepwise Mechanisms Proposed for Other Matrix Metalloproteinases", vol. 31, No. 36, pp. 8500-8507.
Murphy, G., et al., The Journal of Biological Chemistry (1992), "The Role of the C-terminal Domain in Collagenase and Stromelysin Specificity", vol. 267, No. 14, pp. 9612-9618.
Niedzwiecki, L., et al., Biochemistry (1992), "Substrate Specificity of the Human Matrix Metalloproteinase Stromelysin and the Development of Continuous Fluorometric Assays", vol. 31, No. 50, pp. 12618-12623.
Flannery, C.R., et al., The Journal of Biological Chemistry (1992), "Identification of a Stromelysin Cleavage Site within the Interglobular Domain of Human Aggrecan", vol. 267, No. 2, pp. 1008-1014.
Harrison, R.K., et al., Biochemistry (1992), "Mechanistic Studies on the Human Matrix Metalloproteinase Stromelysin", vol. 31, No. 44, pp. 10757-10762.
Salowe, S.P., et al., Biochemistry (1992), "Characterization of Zinc-Binding Sites in Human Stromelysin-1: Stoichiometry of the Catalytic Domain and Identification of a Cysteine Ligand in the Proenzyme", vol. 31, No. 19, pp. 4535-4540.
Ye, Q. et al., Biochemistry (1992), "Purification and Characterization of the Human Stromelysin Catalytic Domain Expressed in Escherichia coli", vol. 31, No. 45, pp. 11231-11235.
Wu, J-J., et al., The Journal of Biological Chemistry (1991), "Sites of Stromelysin Cleavage in Collagen Types II, IX, X, and XI of Cartilage", vol. 266, No. 9, pp. 5625-5628.
Nixon, J.S., et al., Int. J. Tiss. Reac. (1991), "Potent Collagenase Inhibitors Prevent Interleukin-1-Induced Cartilage Degradation In Vitro", vol. 13, No. 5, pp. 237-243.
Marcy, A.I., et al., Biochemistry (1991), "Human Fibroblast Stromelysin Catalytic Domain: Expression, Purification, and Characterization of a C-Terminally Truncated Form", vol. 30, No. 26, pp. 6476-6483.
Brinckerhoff, C.E., Arthritis and Rheumatism (1991), "Joint Destruction in Arthritis: Metalloproteinases in the Spotlight", vol. 34, No. 9, pp. 1073-1075.
Basset, P., et al., Nature (1990), "A Novel Metalloproteinase Gene Specifically Expressed in Stromal Cells of Breast Carcinomas", vol. 348, No. 20/27, pp. 699-703.
Johnson, W.H., Drug News & Perspectives (1990), "Collagenase Inhibitors", vol. 3, No. 8, pp. 453-458.
Shinmei, M., Seminars in Arthritis and Rheumatism (1990), "The Mechanism of Cartilage Degradation in Osteoarthritic Joints", vol. 19, No. 4, pp. 16-20.
Rosenberg, G.A., Stroke (1990), "Collagenase-Induced Intracerebral Hemorrage in Rats", vol. 21, No. 5, pp. 801-807.
Henderson, B., et al., Drugs of the Future (1990), "Design of Inhibitors of Articular Cartilage Destruction", vol. 15, No. 5, pp. 495-508.
Dieppe, P.A., et al., Arthritis and Rheumatism (1988), "Synovial Fluid Collagenase in Patients with Destructive Arthritis of the Shoulder Joint", vol. 31, No. 7, pp. 882-890.
Johnson, W.H., et al., J. Enzyme Inhibition (1987), "Collagenase Inhibitors: Their Design and Potential Therapeutic Use", vol. 2, pp. 1-22.
Liotta, L.A., et al., Ann. Rev. Biochem. (1986), "Biochemical Interactions of Tumor Cells with the Basement Membrane", vol. 55, pp. 1037-1057.
Kerwar, S.S., et al., Advances in Inflammation Research (1986), "Inhibitors of Connective-Tissue Breakdown and their Use in Inflammatory Disease", vol. 11, pp. 159-171.
Mainardi, C.L., et al., Advances in Inflammation Research (1986), "Type-Specific Collagenolysis", vol. 11, pp. 135-144.
Turpeenniemi-Hujanen, T., et al., Annual Reports in Medicinal Chemistry (1984), "Collagenases in Tumor Cell Extravasation", Chapter 23, pp. 231-239.
Liotta, L.A., et al., Cancer Metastasis Reviews 1 (1982), "Role of Collagenases in Tumor Cell Invasion", pp. 277-288.
Manabe, R., et al., Int. Congr. Ser. --Excerpta Med. (1982), "Collagenase in Eye Diseases", vol. 61, pp. 231-240.
Harper, E., et al., Ann. Rev. Biochem. (1980), "Collagenases", vol. 49, pp. 1063-1078.
Bender Steven Lee
Castelhano Arlindo Lucas
Deal Judith Gail
Horne Stephen
Liak Teng J.
Stockton Laura L.
Syntex (U.S.A.) Inc.
LandOfFree
Matrix metalloprotease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Matrix metalloprotease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Matrix metalloprotease inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-170605