Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2011-08-30
2011-08-30
Robinson, Hope (Department: 1652)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S094640, C424S085500, C514S012200, C514S002600
Reexamination Certificate
active
08007774
ABSTRACT:
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration.
REFERENCES:
patent: 4925924 (1990-05-01), Silver et al.
patent: 4970298 (1990-11-01), Silver et al.
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5567435 (1996-10-01), Hubbell et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5614587 (1997-03-01), Rhee et al.
patent: 5626863 (1997-05-01), Hubbell et al.
patent: 5733563 (1998-03-01), Fortier
patent: 5834274 (1998-11-01), Hubbell et al.
patent: 5843743 (1998-12-01), Hubbell et al.
patent: 5858746 (1999-01-01), Hubbell et al.
patent: 5863984 (1999-01-01), Doillon et al.
patent: 5902599 (1999-05-01), Anseth et al.
patent: 5986043 (1999-11-01), Hubbell et al.
patent: 6060582 (2000-05-01), Hubbell et al.
patent: 6153211 (2000-11-01), Hubbell et al.
patent: 6224893 (2001-05-01), Langer et al.
patent: 6306922 (2001-10-01), Hubbell et al.
patent: 6403672 (2002-06-01), Randolph et al.
patent: 6565842 (2003-05-01), Desai et al.
patent: 6703037 (2004-03-01), Hubbell et al.
patent: 6858229 (2005-02-01), Hubbell et al.
patent: 6864301 (2005-03-01), Randolph et al.
patent: 6911227 (2005-06-01), Hubbell et al.
patent: 7842667 (2010-11-01), Seliktar et al.
patent: 2004/0082511 (2004-04-01), Watzek et al.
patent: 2006/0233855 (2006-10-01), Seliktar et al.
patent: 0605797 (1994-07-01), None
patent: 0680990 (1995-11-01), None
patent: 0976759 (2000-02-01), None
patent: WO 98/32466 (1998-07-01), None
patent: WO 99/34833 (1999-07-01), None
patent: WO 01/53324 (2001-07-01), None
patent: WO 02/18441 (2002-07-01), None
patent: WO 2004/041298 (2004-05-01), None
patent: WO 2005/061018 (2005-07-01), None
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Hooftman et al. “Review: Poly(Ethylene Glycol)s With Reactive Endgroups. II. Practical Consideratiion for the Preparation of Protein-PEG Conjugates”, Journal of Bioactive and Compatible Polymers, 11: 135-159, 1996.
Deible et al. “Molecular Barriers to Biomaterial Thrombosis by Modification of Surface Proteins With Polyethylene Glycol”, Biomaterials, 19: 1885-1893, 1998.
Veronese “Peptide and Protein PEGylation: A Review of Problems and Solutions”, Biomaterials, 22: 405-417, 2001.
Li et al. “Synthesis of Polyethylene Glycol (PEG) Derivatives and PEGylated-Peptide Biopolymer Conjugates”, Biomacromolecules, 4: 1055-1067, 2003.
Zalipsky “Chemistry of Polyethylene Glycol Conjugates With Biologically Active Molecules”, Advanced Drug Delivery Reviews, 16: 157-182, 1995.
Almany et al. “Biosynthetic Hydrogel Scaffolds Made From Fibrinogen and Polyethylene Glycol for 3D Cell Cultures”, Biomaterials, 26: 2467-2477, 2005.
Seliktar et al. “MMP-2 Sensitive, VEGF-Bearing Bioactive Hydrogels for Promotion of Vascular Healing”, Journal of Biomedical Materials Research—Part. A, 68(4): 704-716, 2004. Abstract.
Gayet et al. “Drug Release From New Bioartificial Hydrogel”, Art. Cells, Blood Subs., and Immob. Biotech., 23(5): 605-611, 1995.
D'Urso et al. “Poly(Ethylene Glycol)-Serum Albumin Hydrogel as Matrix for Enzyme Immobilization: Biomedical Applications”, Art. Cells, Blood Subs., and Biotech., 23(5): 587-595, 1995.
Dikovsky et al. “The Effect of Structural Alterations of PEG-Fibrinogen Hydrogel Scaffolds on 3-D Cellular Morphology and Cellular Migration”, Biomaterials, 27(8): 1496-1506, 2005. Abstract, p. 1497, § 2.1, 2.2.
Halstenberg et al. “Biologically Engineered Protein-Graft-Poly(Ethylene Glycol) Hydrogels: A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair”, Biomacromolecules, 3(4): 710-723, 2002. Abstract, p. 713, Co1.2, § 3-p. 714, col. 1, § 2.
Official Action Dated Oct. 4, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Official Action Dated Nov. 12, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Official Action Dated Jun. 15, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Official Action Dated Apr. 28, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Communication Pursuant to Article 94(3) EPC Dated Jan. 5, 2009 From the European Patent Office Re.: Application No. 04806668.2.
Communication Pursuant to Article 96(2) EPC Dated Dec. 11, 2006 From the European Patent Office Re.: Application No. 04806668.2.
Communication Pursuant to Article 94(3) EPC Dated Jan. 5, 2009 From the European Patent Office Re.: Application No. 04806668.2.
Communication Pursuant to Article 94(3) EPC Dated Jul. 25, 2008 From the European Patent Office Re.: Application No. 07110777.5.
Communication Pursuant to Article 96(2) EPC Dated Dec. 11, 2006 From the European Patent Office Re.: Application No. 04806668.2.
European Search Report Dated Oct. 22, 2007 From the European Patent Office Re.: Application No. 07110777.5.
International Preliminary Report on Patentability Dated Jul. 6, 2006 From the International Bureau of WIPO Re.: Application No. PCT/IL2004/001136.
International Search Report Dated Jun. 1, 2005 From the International Searching Authority Re.: Application No. PCT/IL2004/001136.
Written Opinion Dated Jun. 1, 2005 From the International Searching Authority Re.: Application No. PCT/IL2004/001136.
Response Dated Oct. 19, 2009 to Official Action of Jul. 22, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Official Action Dated Feb. 4, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Official Action Dated Jan. 21, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,437.
Response Dated Oct. 19, 2009 to Official Action of Jul. 22, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Response Dated Jan. 28, 2010 to Communication Pursuant to Article 94(3) EPC of Jul. 6, 2009 From the European Patent Office Re.: Application No. 04806668.2.
Meyers et al. “A Fibrin Adhesive Seal for the Repair of Osteochondral Fracture Fragments”, Clinical Orthopaedics and Related Research, 182: 258-263, Jan.-Feb. 1984.
Pflüger et al. “Untersuchungen über das Einwachsen von Knochengewebe in poröse Metallimplantate”, Wiener Klinische Wochenschrift, 91(14): 482-487, Jul. 13, 1979.
Response Dated May 3, 2010 to Official Action of Feb. 4, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/472,520.
Response Dated Oct. 18, 2010 to Invitation Pursuant to Article 94(3) and Rule 71(1) EPC of Jun. 10, 2010 From the European Patent Office Re. Application No. 04806668.2.
European Search Report and the European Search Opinion Dated May 20, 2011 From the European Patent Office Re. Application No. 10012382.7.
Almany Liora
Seliktar Dror
Regentis Biomaterials Ltd.
Robinson Hope
LandOfFree
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