Mass spectrometer system

Radiant energy – Ionic separation or analysis

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C250S282000, C250S288000, C250S290000

Reexamination Certificate

active

07932486

ABSTRACT:
During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSnspectrum is effectively utilized in each step of the MSninvolving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.

REFERENCES:
patent: 6894276 (2005-05-01), Takada et al.
patent: 7057169 (2006-06-01), Takada et al.
patent: 2002/0027195 (2002-03-01), Kato
patent: 2003/0009661 (2003-01-01), Tsutsumi et al.
patent: 2004/0181347 (2004-09-01), Yoshinari et al.
patent: 2004/0222369 (2004-11-01), Makarov et al.
patent: 2005/0199801 (2005-09-01), Takada et al.
patent: 2006/0169889 (2006-08-01), Yokosuka et al.
patent: 2006/0192101 (2006-08-01), Takada et al.
patent: 2006/0289735 (2006-12-01), Ohtake et al.
patent: 10-142196 (1998-05-01), None
patent: 2000-243347 (2000-09-01), None
patent: 2001-249114 (2001-09-01), None
patent: 2002-184348 (2002-06-01), None
patent: 2003-014695 (2003-01-01), None
patent: WO 02/25265 (2002-03-01), None
Dirk A. Wolters et al., “An automated multidimensional protein identification technology for shotgun proteomics,” Analytical Chemistry, vol. 73, No. 23, pp. 5683-5690, Dec. 1, 2001.
Thermo Finnigan Product Support Bulletin, “Dynamic exclusion,” PSB 105, pp. 1-2.
Wolfgan Paul, “Electromagnetic traps for charged and neutral particles,” Reviews of Moderrn Physics, vol. 62, No. 3, pp. 531-540, Jul. 1990.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Mass spectrometer system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mass spectrometer system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mass spectrometer system will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2658443

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.