Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-11-24
2011-11-29
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C436S518000
Reexamination Certificate
active
08067180
ABSTRACT:
Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.
REFERENCES:
patent: 6183962 (2001-02-01), Acton
International Human Genome Sequencing Consortium.Homo sapiensKIAA0551 protein (KIAA0551), mRNA. GI:22041067 Jan. 3, 2003.
Nagase,T., et al.Homo sapiensmRNA for KIAA0551 protein, partial cds. GI:20521082 May 10, 2002.
Kawakami,T., et al.Homo sapienscDNA: FLJ22817 fis, clone KAIA3476, highly similar to AF172271 Homo sapiens Traf2 and NCK interacting kinase splice variant 8 (TNIK) mRNA. GI:10439341 Sep. 13, 2003.
Fu,C.A., et al.Homo sapiensTraf2 and NCK interacting kinase, splice variant 3 (TNIK) mRNA, complete cds. GI:6110351 Oct. 25, 1999.
Fu,C.A., et at.Homo sapiensTraf2 and NCK interacting kinase, splice variant 5 (TNIK) mRNA, complete cds. GI:6110356 Oct. 25, 1999.
Fu,C.A., et at.Homo sapiensTraf2 and NCK interacting kinase, splice variant 6 (TNIK) mRNA, complete cds. GI:6110359 Oct. 25, 1999.
Fu,C.A., et al.Homo sapiensTraf2 and NCK interacting kinase, splice variant 7 (TNIK) mRNA, complete cds. GI:6110361 Oct. 25, 1999.
Fu,C.A., et al.Homo sapiensTraf2 and NCK interacting kinase, splice variant 8 (TNIK) mRNA, complete cds. GI:6110364 Oct. 25, 1999.
Strausberg,R.Homo sapiens, clone IMAGE:4651684, mRNA, partial cds. GI:17512195 Dec. 11, 2001.
Fu,C.A., et al.Homo sapiensTraf2 and NCK interacting kinase, splice variant 2 (TNIK) mRNA, complete cds. GI:6110349 Oct. 25, 1999.
Strausberg,R.L., et al.Homo sapiensTRAF2 and NCK interacting kinase, mRNA (cDNA clone IMAGE:4838784), complete cds. GI:33416309 Jul. 28, 2005.
Wright,J.H., et alHomo sapiensmitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), transcript variant 1, mRNA. GI:22035601 Dec. 20, 2003.
Yao,Z., et al.Homo sapiensmitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), mRNA. GI:4758523 Nov. 1, 2000.
NCBI Annotation Project.Homo sapiensmitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), mRNA. GI:18553055 Feb. 6, 2002.
Ishikawa,K., et al.Homo sapiensmRNA for KIAA0687 protein, partial cds. GI:3327187 Feb. 6, 1999.
Bahr,A., et al.Homo sapiensmRNA; cDNA DKFZp434A025 (from clone DKFZp434A025). GI:6808458 Apr. 16, 2005.
Kawabata,A., et al.Homo sapienscDNA: FLJ21957 fis, clone HEP05344. GI:10438179 Sep. 13, 2003.
Ota,T., et al.Homo sapienscDNA FLJ10410 fis, clone NT2RP1000018, highly similar to Homo sapiens mRNA for KIAA0687 protein. GI:7022424 Jan. 30, 2004.
Wright,J.H., et al.Homo sapiensmitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), transcript variant 2, mRNA. GI:22035603 Dec. 21, 2003.
Wright,J.H., et al.Homo sapiensmitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), transcript variant 3, mRNA. GI:22035605 Dec. 21, 2003.
Dan,I., et al.Homo sapiensMisshapen/NIK-related kinase (MINK), mRNA. GI:7657334 Dec. 10, 2001.
Strausberg,R.L., et al.Homo sapiensmisshapen-like kinase 1 (zebrafish), transcript variant 3, mRNA (cDNA clone MGC:21111 IMAGE:4384442), complete cds. GI:21961594 Jul. 9, 2005.
Dan,I., et al.Homo sapiensCHRNE, MINK genes for AchR epsilon subunit, GCK family kinase, partial cds. GI:21321027 Jul. 3, 2002.
Ota,T., et al.Homo sapienscDNA FLJ39291 fis, clone OCBBF2012436, highly similar to Homo sapiens mRNA for Misshapen/NIK-related kinase MINK-1. GI:21756143 Jan. 30, 2004.
Hu,Y., et al.Homo sapiensmisshapen-like kinase 1 (zebrafish) (MINK1), transcript variant 1, mRNA. GI:27436915 Aug. 25, 2005.
Hu,Y., et al.Homo sapiensmisshapen-like kinase 1 (zebrafish) (MINK1), transcript variant 3, mRNA. GI:27436916 Aug. 25, 2005.
Hu,Y., et al.Homo sapiensmisshapen-like kinase 1 (zebrafish) (MINK1), transcript variant 2, mRNA. GI:27436918 Aug. 25, 2005.
International Human Genome Sequencing Consortium.Homo sapienssimilar to NIK-related kinase (LOC203447), mRNA. GI:20549227 Apr. 28, 2003.
NCI-CGAP. on05g09.y5 NCI—CGAP—Kid3Homo sapienscDNA clone IMAGE:1555840 5′ similar to TR:O60298 O60298 KIAA0551 PROTEIN ;, mRNA sequence. GI:5340679 Dec. 13, 1999.
Lauber,J., et al.Homo sapiensmRNA; cDNA DKFZp686A17109 (from clone DKFZp686A17109); complete cds. GI:31874847 Apr. 17, 2005.
Fu,C.A., et al. Traf2 and NCK interacting kinase, splice variant 2 [Homo sapiens]. GI:6110350 Oct. 25, 1999.
Beausoleil,S.A., et al. mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [Homo sapiens]. GI:22035602 Apr. 23, 2005.
Hu,Y., et al. misshapen/NIK-related kinase isoform 1 [Homo sapiens]. GI:7657335 Aug. 25, 2005.
International Human Genome Sequencing Consortium. similar to NIK-related kinase [Homo sapiens]. GI:20549228 Apr. 28, 2003.
MacDonald T et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nature Genetics 29:143-152. 2001.
Li Chaohong et al.: “Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways,” Journal of biological Chemistry, vol. 274, No. 36; Sep. 1999, pp. 25273-25850.
Zhang Yi et al.: “Axin forms a complex with MEKK1 and activates c-Jun Nh2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling,” Journal of Biological Chemistry, vol. 274, No. 49; Dec. 3, 1999, pp. 35247-35254.
Sun T-Q et al.: “PAR-1 is a Dishevelled-Assoicated kinase and a positive regulator of WNT signalling,” Nature Cell Biology, vol. 3, No. 7, Jul. 2001, pp. 628-636.
Macdonald et al.: “Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease,” Nat Genet. 2001, vol. 29. No. 2 pp. 143-152.
Anad—Apte et al.: “Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways,” Journal Biol. Chem., Oct. 5, 1997, vol. 272, No. 49, pp. 30688-30692.
Liou et al.: “MAP kinase and beta-catenin signaling in HGF induced RPE migration,” Mol. Vis., Dec. 20, 2002, vol. 8, pp. 486-493.
Costa Michael R.
Dora, III Emery G.
Francis George Ross
Gendreau Steven Brian
Kadyk Lisa C.
Cheu Jacob
Exelixis Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
LandOfFree
MAPKs as modifiers of the rac, axin, and beta-catenin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with MAPKs as modifiers of the rac, axin, and beta-catenin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MAPKs as modifiers of the rac, axin, and beta-catenin... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4284821