Manufacture and purification of cyclosporin A

Details Manufacture and purification of cyclosporin A Manufacture and purification of cyclosporin A

2007-02-13

2007-02-13

Witz, Jean C. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

C435S071300, C435S243000

Reexamination Certificate

active

10220226

ABSTRACT:
The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation ofFusarium solaniin a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.

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