Mammalian SUV39H2 proteins and isolated DNA molecules...

Details Mammalian SUV39H2 proteins and isolated DNA molecules... Mammalian SUV39H2 proteins and isolated DNA molecules...

2006-05-30

2006-05-30

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S252330, C435S320100, C435S471000, C536S023200, C536S023100, C536S023500

Reexamination Certificate

active

07052889

ABSTRACT:
Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with Suv39h1, for male gametogenesis. Suv39h2 can be used in screening methods to identify modulators of its methyltransferase activity, which are useful in cancer therapy and for male contraception.

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