Malonyl-CoA decarboxylase inhibitors useful as metabolic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S106000, C544S158000, C544S159000, C544S160000, C514S231200, C514S237500, C548S240000, C548S300100, C548S335100, C548S356100

Reexamination Certificate

active

10466926

ABSTRACT:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

REFERENCES:
patent: 5177097 (1993-01-01), Poss
patent: 5190942 (1993-03-01), Poss
patent: 5208234 (1993-05-01), Poss
patent: 5208235 (1993-05-01), Poss
patent: 5212177 (1993-05-01), Poss
patent: 5225408 (1993-07-01), Weller
patent: 5256695 (1993-10-01), Poss
patent: 5374615 (1994-12-01), Poss
patent: 5378704 (1995-01-01), Weller
patent: 5428033 (1995-06-01), Belley
patent: 5470975 (1995-11-01), Atwal
patent: 5512681 (1996-04-01), Boswell
patent: 5519143 (1996-05-01), Harris
patent: 5534347 (1996-07-01), Chen
patent: 5736297 (1998-04-01), Roeschert
patent: 5895771 (1999-04-01), Epstein
patent: 5977413 (1999-11-01), Tomaru
patent: 6316503 (2001-11-01), Li et al.
patent: 197 16 231 (1998-10-01), None
patent: 197 22 952 (1998-12-01), None
patent: 0 296 722 (1988-12-01), None
patent: 0 481 448 (1992-04-01), None
patent: 0 547 442 (1993-06-01), None
patent: 0 556 060 (1993-08-01), None
patent: 0 733 366 (1996-09-01), None
patent: 0 733 614 (1998-05-01), None
patent: 0 916 352 (1998-12-01), None
patent: 2 784 114 (2000-04-01), None
patent: 2 321 244 (1998-07-01), None
patent: 2 337 701 (1999-01-01), None
patent: 08 311036 (1996-11-01), None
patent: 09 012585 (1997-01-01), None
patent: 1743153 (1995-02-01), None
patent: 1825496 (1994-12-01), None
patent: WO87/05297 (1987-09-01), None
patent: WO91/00277 (1991-01-01), None
patent: WO91/00281 (1991-01-01), None
patent: WO92/00067 (1992-01-01), None
patent: WO93/21158 (1993-10-01), None
patent: WO93/21168 (1993-10-01), None
patent: WO94/10692 (1994-05-01), None
patent: WO94/14453 (1994-07-01), None
patent: WO94/15932 (1994-07-01), None
patent: WO9418606 (1994-08-01), None
patent: WO95/35311 (1995-12-01), None
patent: WO95/35312 (1995-12-01), None
patent: WO95/35313 (1995-12-01), None
patent: WO96/13491 (1996-05-01), None
patent: WO96/13500 (1996-05-01), None
patent: WO99/12938 (1999-03-01), None
patent: WO99/47497 (1999-09-01), None
patent: WO 00/20472 (2000-04-01), None
patent: WO 00/34344 (2000-06-01), None
patent: WO 00/37422 (2000-06-01), None
patent: WO 00/46203 (2000-08-01), None
patent: WO 00/54759 (2000-09-01), None
patent: WO 00/56710 (2000-09-01), None
patent: WO 01/03705 (2001-01-01), None
patent: WO 02/058690 (2002-08-01), None
Abo-Hashema, et al., Biochemistry, 1999, 15840-15847, vol. 38.
Abo-Hashema, et al., Journal of Biological Chemistry, 1999, 35577-35582, Vo. 274, No. 50.
Alam and Saggerson, Bichen J., 1998, 233-241, vol. 334.
An, et al., Journal of Biochemistry and Molecular Biology, 1999, 414-418, vol. 32, No. 4.
Anderson, Current Pharmaceutical Design, 1998, 1-16, vol. 4, No. 1.
Buckner, et al., Archives of Biochemistry and Biophysics, 1976, 539-551, vol. 177.
Deems, et al., The American Physiological Society, 1998, R524-R528, vol. 274.
Dyck, et al., The American Physiological Society, 1998, H2122-H2129, vol. 275.
Farah, et al., Journal of Organic Chemistry, 1965, 998-1001, vol. 30, No. 4.
Fitzpatrick, et. al., Am. J. Hum. Genet. 1999, 318-326, vol. 65.
Fraser, et al., Febs Letters, 1999, 69-74, vol. 446.
Fujisawa, et al., TETRAHEDRON, 1998, 4267-4276, vol. 54, No. 17.
Gao, et al., Journal of Lipid Research, 1999, 178-182, vol. 40.
Hatanaka, et al., Heterocycles, 1993, 997-1004, vol. 35, No. 2.
Hearse, Metabolic Approaches to Ischaemic Heart Disease and its Management, Science Press, London, UK.
Jang, et al., The Journal of Biological Chemistry, 1989, 3500-3505, vol. 264, No. 6.
Kantor, et al., Circulation Research, 2000, 580-588, vol. 86.
Kennedy, et. al., Biochemical Pharmacology, 1996, 273-280, vol. 52.
Kim and Kolattukudy, Archives of Biochemistry and Biophysics, 1978, 585-597, vol. 190, No. 2.
Kim and Kolattukudy, Archives of Biochemistry and Biophysics, 1978, 234-246, vol. 190, No. 1.
Kim and Kolattukudy, Biochimica et Biophysica Acta, 1978, 187-196, vol. 531.
Loftus, et al., Science, 2000, 237-238, vol. 288.
McCormack, et al., Gen. Pharmac., 1998, 639-645, vol. 30, No. 5.
McGarry and Brown, Eur. J. Biochem, 1997, 1-14, vol. 244.
McNeill, Measurement of Cardiovascular Func., CRC Press, Boca Raton, USA.
Naae, J. Org. Chem., 1977, 1780-1783, vol. 42, No. 10.
Nassal, Liebigs Annalen Der Chemie, 1983, 1510-1523, No. 9.
Pepine and Wolff, The American Journal of Cardiology, 1999, 46-50, vol. 84.
Pizer, et al., Cancer Research, 2000, 213-218, vol. 60.
Prentki and Corkey, Diabetes, 1996, 273-283, vol. 45.
Randle, et al., Lancet, 1963, 785 789, vol. 1.
Sacksteder, et al., The Journal of Biological Chemistry, 1999, 24461-24468, vol. 274, No. 35.
Voilley, et al., Biochem J., 1999, 213-217, vol. 340.
Wagner, et al., Journal of The American Chemical Society, 1986, 7727-7738, vol. 108, No. 24.
Wargovich, et. al., Am J Cardiol, 1988, 65-70, vol. 61.
Zammit, Biochemical Society, 1999, 505-515, vol. 343.
Database Caplus ′Online!, Chemical Abstracts Service, XP002230054, 1999, 851-858, vol. 93, No. 8.
“Fluka Chemika-Biochemika” Fluka Chemie AG, Buchs (CH), XP002230053, 1995, 331.

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