Malonic acid monoesters and process for producing the same

Details Malonic acid monoesters and process for producing the same Malonic acid monoesters and process for producing the same

2003-10-17

2009-06-30

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S192000

Reexamination Certificate

active

07553989

ABSTRACT:
The present invention relates to a compound represented by formula (1) or a salt thereof:wherein R represents a group that is easily removable upon hydrolysis in vivo. This compound is usable in the production of prodrug-type carbapenem antibacterial agents for oral administration. The use of this compound in the process of production of the antibacterial agents can realize enhanced production efficiency and reduced production cost.

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Liebich et al, Journal of Chromatography B: Biomedical Sciences and Applications, Urinary Organic Acid Screening by Solid-phase Microextraction of the Methyl Esters, 1998, 713(2), pp. 427-432.

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