Macrophage stimulating protein variant and method for producing

Details Macrophage stimulating protein variant and method for producing Macrophage stimulating protein variant and method for producing

1996-06-19

1999-06-29

Schwardron, Ronald B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 696, 4352523, 43525411, 4353201, 435325, 435360, 4353651, 530350, 530351, 530380, 530395, 530403, 536 231, 536 235, 935 6, 935 10, 935 22, 935 27, 935 31, 935 32, 935 68, 935 70, C12N 1519, C12N 1500, C12N 1563, C07K 1452

Patent

active

059167700

ABSTRACT:
The present invention relates to a macrophage stimulating protein wherein a cysteine residue at position 672 from the N-terminus in the amino acid sequence of native form macrophage stimulating protein is deleted or substituted by another amino acid residue, e.g., an alanine residue; a DNA fragment encoding the protein; a recombinant vector including the DNA fragment; a host cell transformed with the recombinant vector; and a method for culturing the transformed host cell and recovering a macrophage stimulating protein variant from the cultured host cell.

REFERENCES:
patent: 5219991 (1993-06-01), Leonard et al.
patent: 5315000 (1994-05-01), Degen
patent: 5446020 (1995-08-01), Andy et al.
Exp. Cell. Res., vol. 102, pp. 434-438, 1976. A Serum Protein that Stimulates Macrophage Movement, Chemotaxis and Spreading, E.J. Leonard and Alison Skeel.
The Journal of Experimental Medicine, vol. 173, pp. 1227-1234, 1991. Macrophage Stimulating Protein: Purification, Partial Amino Acid Sequence, and Cellular Activity, Alison Skeel, Teizo Yoshimura, Stephen D. Showalter, Shuji Tanaka, Ettore Appella, and Edward J. Leonard.
Biochemistry, vol. 30, No. 40, pp. 9768-9780, 1991. Characterization of the DNF15S2 Locus on Human Chromosome 3: Identification of a Gene Coding for Four Kringle Domains with Homology to Hepatocyte Growth Factor, Su Han, Lorie A. Stuart, and Sandra J. Friezner Degen.
The Journal of Biological Chemistry, vol. 268, No. 21, pp. 15461-15468, 1993. Cloning, Sequencing, and Expression of Human Macrophage Stimulating Protein (MSP, MST1) Confirms MSP as a Member of the Family of Kringle Proteins and Locates the MSP Gene on Chromosome 3, Teizo Yoshimura, Naoya Yuhki, Ming-Hai Wang, Alison Skeel, and Edward J. Leonard, pp. 15461-15468, Jul. 25, 1993.
The Journal of Biological Chemistry, vol. 269, No. 5, pp. 3436-3440, 1994. Proteolytic Conversion of Single Chain Precursor Macrophage-stimulating Protein to a Biologically Active Heterodimer by Contact Enzymes of The Coagulation Cascade, Ming-Hai Wang, Teizo Yoshimura, Alison Skeel, and Edward J. Leonard.
Biochemistry, vol. 27, No. 21, pp. 8097-8105, 1988. The Structure of Rat Mast Cell Protease II at 1.9-.ANG. Resolution, Stephen J. Remington, Richard G. Woodbury, Ross A. Reynolds, Brian W. Matthews, and Hans Neurath.
Biochemistry, vol. 23, No. 26, pp. 6570-6575, 1984. Critical Evaluation of Comparative Model Building of Streptomyces Griseus Trypsin, Randy J. Read, Gary D. Brayer, Lubomir Jurasek, and Michael N. G. James, pp. 6570-6575, 1984.
Journal of Leukocyte Biology, vol. 54, pp. 289-295, 1993. Antibodies to Machrophage Stimulating Protein (MSP): Specificity, Epitope interactions, and immunoassay of MSP in Human Serum, Ming-Hai Wang, Alison Skeel, Teizo Yoshimura, Terry D. Copeland, Kazuyasu Sakaguchi, and Edward J. Leonard.

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