Eleutherobin and analogs thereof

Details Eleutherobin and analogs thereof Eleutherobin and analogs thereof

1994-11-09

1995-12-05

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 181, 536 182, C07H 1500, C07H 1700

Patent

active

054730570

ABSTRACT:
Eleutherobin is a glycosylated diterpene which has the structural formula: ##STR1## Eleutherobin is a cytotoxic agent which is toxic to carcinoma cancer cells. Analogs of eleutherobin are also disclosed.

REFERENCES:
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D'Ambrosio et al., "189.Sarcodictyin A and Sarcodictyin B, Novel Diterpenoidic Alcohols Esterified by (E)-N(1)-Methylurocanic Acid. Isolation from the Mediterranean Stolonifer Sarcodictyon roseum," Helvetica Chimica Acta-vol. 70, pp. 2019-2027 (1987).
D'Ambrosio et al., "105.Isolation from the Mediterranean Stoloniferan Coral Sarcodictyon roseum of Sarcodictyin C, D, E, and F, Novel Diterpenoidic Alcohols Esterifieid by (E)-or (Z)-N(1)-Methylurocanic Acid. Failure of the Carbon-Skeleton Type as a Classification Criterion)", Helvetica Chimica Acta, vol. 71, pp. 964-977 (1988).
Lin et al., "The Valdivones, Anti-inflammatory Diterpene Esters from the South African Soft Coral Alcyonium valdivae," Tetrahedron, vol. 49, No. 36, pp. 7977-7984 (1993).
Kazlauskas et al., "Two New Diterpenes Related to Eunicellin from a Cladiella Species (Soft Coral)," Tetr. Ltrs., No. 52, pp. 4643-4646 (1977).

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