Macrophage inflammatory protein-3 and -4

Details Macrophage inflammatory protein-3 and -4 Macrophage inflammatory protein-3 and -4

1994-03-08

1996-04-02

Furman, Keith C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 691, 4352523, 4351723, 4353201, 424 852, 424 932, 424 9321, 530350, 530351, 514 2, 514 12, 536 221, 536 231, 536 235, 935 57, C12N 510, C12N 1512, C12P 2106, A61K 3800

Patent

active

055040039

ABSTRACT:
There is disclosed a human macrophage inflammatory protein-3 (MIP-3) and a human macrophage inflammatory protein-4 (MIP-4) polypeptides and DNA (RNA) encoding such polypeptides. There is also provided a procedure for producing such polypeptides by recombinant techniques and for producing antibodies against such polypeptides. In the invention there is also provided antagonist/inhibitors against such polypeptides which inhibit the functioning of such polypeptides. Another aspect of the invention provides a combination of the polypeptides of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptides for the treatment of various associated diseases.

REFERENCES:
Kwon et al., "cDNA sequences of two inducible T-cell genes," Proc. Natl. Acad. Sci., USA vol. 86, pp. 1963-1967, Mar., 1989.
Nakao et al., "Structures of Human Genes Coding for Cytokine LD78 and Their Expression," Mol. Cell. Biol., vol. 10, No. 7, pp. 3646-3658, Jul. 1990.

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