Macrocyclic NS-3 serine protease inhibitors of hepatitis C...

Details Macrocyclic NS-3 serine protease inhibitors of hepatitis C... Macrocyclic NS-3 serine protease inhibitors of hepatitis C...

2005-07-05

2005-07-05

Low, Christopher S. F. (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C514S011400

Reexamination Certificate

active

06914122

ABSTRACT:
The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.

REFERENCES:
patent: 4260601 (1981-04-01), Reichelt et al.
patent: 4499081 (1985-02-01), Laerum
patent: 4956344 (1990-09-01), Fossli et al.
patent: 5712145 (1998-01-01), Houghton et al.
patent: 5874529 (1999-02-01), Gilon et al.
patent: 6265375 (2001-07-01), Gilon et al.
patent: 6407066 (2002-06-01), Dressen et al.
patent: 6569993 (2003-05-01), Sledeski et al.
patent: 381 216 (1990-08-01), None
patent: 53-77083 (1978-07-01), None
patent: 7-228594 (1995-08-01), None
patent: WO 89/04669 (1989-06-01), None
patent: WO 00/09558 (1998-02-01), None
patent: WO 98/07734 (1998-02-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/22496 (1998-05-01), None
patent: WO 99/64442 (1999-06-01), None
patent: WO 00/09543 (2000-05-01), None
Marchetti, Synlett (Spec.), 1000_1002, 1999.
Koiso Journal of Antibiotics 47, 765, 1994.
Dutta, J. Med. Chem. 33, 2552 1990.
Pizzi, (1994)Proc. Natl. Acad. Sci(USA) 91:888-892.
Failla (1996)folding&Design1:35-42.
Kollykhalov (1994)J. Virol. 68:7525-7533.
Komoda (1994)J. Virol. 68:7351-7357.
Landro (1997)Biochem36:9340-9348.
Ingallinella (1998)Biochem37:8906-8914.
Llinas-Brunet (1998)Bioorg. Med. Chem. Lett, 8:1713-1718.
Martin (1998)Biochem37:11459-11468.
Dimasi (1997)J. Virol. 71:7461-7469.
Martin (1997)Protein Eng. 10:607-614.
Elzouki (1997)J. Hepat. 27:42-48.
Bio World Today9(217): 4 (Nov. 10, 1998).
Berenguer (1998)Proc. Assoc. Am. Physicians110(2): 98-112.
Hoofnagle (1997)New England Journal Med. 336:347.
ZhangAnalytical Biochemistry270:268-275 (1999).
Sali (1998)Biochemistry3392-3401.
Barlos (1991)Int. J. Pept. Protein Res513-520.
Holmberg (1979)Acta Chem. Scand., B33:410-412.
Agrawal(1999)Hepatology Supplement to vol 30“Development and Characterization of Hepatitis C Virus Serine Protease Cell-based Trans-Cleavage Assay”.
Hughes (1992)Org. Reactions42:335.
Heck (1989)Org. Reactions27:345-390.

Affiliated with

Also associated with

Rating

Macrocyclic NS-3 serine protease inhibitors of hepatitis C... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macrocyclic NS-3 serine protease inhibitors of hepatitis C..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic NS-3 serine protease inhibitors of hepatitis C... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3392566