Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-11-04
2009-11-03
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S470000
Reexamination Certificate
active
07612055
ABSTRACT:
The present invention relates to novel macrocyclic compounds of the formulawherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
REFERENCES:
patent: 0 675 122 (1995-10-01), None
patent: WO 92/18490 (1992-10-01), None
Hardy et al. Neuron, 2006, 52, 3-13.
Ripka et al. Bioorganic and Medicinal Chemistry Letters, 1998, 8, 357-360.
Smith, R.A., et al., “Design, Synthesis, and Activity of Conformationally-Constrained Macrocyclic Peptide-Based Inhibitors of HIV Protease,”Bioorg. &Med. Chem. Lett. 4(18):2217-2222 (1994).
Auberson Yves
Betschart Claudia
Glatthar Ralf
Laumen Kurt
Machauer Rainer
Foley & Lardner LLP
Jarrell Noble
Novartis AG
Wilson James O
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