Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1986-09-11
1991-01-22
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435 75, 4352521, 435123, C12P 1718, C12P 1960, C12P 1702, C12N 120
Patent
active
049870726
ABSTRACT:
The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.
The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.
REFERENCES:
patent: 3651216 (1972-03-01), Ringel et al.
Edwards et al., Tetrahedron Letters, vol. 7, No. 40, pp. 4867-4870 (1966).
Jansen et al., Tetrahedron Letters, vol. 26, No. 49, pp. 6031-6034 (1985).
Augustiniak Hermann
Bedorf Norbert
Gerth Klaus
Hofle Gerhard
Irschik Herbert
Gesellschaft fur Biotechnologische Forschung GmbH
Marx Irene
Weimar Elizabeth C.
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