Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-19
2008-11-25
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S456000
Reexamination Certificate
active
07456163
ABSTRACT:
The present invention is macrocycles of the formula (X):for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
REFERENCES:
patent: 6043357 (2000-03-01), Abbenante et al.
Beck James P.
Jacobs Jon S.
Pulley Shon R.
TenBrink Ruth E.
Elan Pharmaceuticals Inc.
Kifle Bruck
McDonnell Boehnen & Hulbert & Berghoff LLP
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