Lysozyme fusion proteins in infections

Details Lysozyme fusion proteins in infections Lysozyme fusion proteins in infections

1998-11-18

1999-11-30

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435206, 435 691, 514 12, 530350, A61K 3816, A61K 3843, A61K 3847

Patent

active

059938099

ABSTRACT:
A method and composition for prophylaxis and/or treatment of bacterial infections, particularly bacterial respiratory infections. A fusion protein of lysozyme and the carboxyl terminal propeptide of surfactant protein-B (SP-B) with the preceding ten amino acids of the mature SP-B peptide is administered in a pharmaceutically acceptable medium to an individual. The fusion protein may be selected so as to deliver it to a target infection site, such as the lungs or gastrointestinal tract. The method and composition eliminates problems associated with conventional antibiotic treatments, such as inefficacy and promotion of antibiotic resistant bacterial strains.

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