Lysin protein having broad antibacterial activity specific...

Details Lysin protein having broad antibacterial activity specific... Lysin protein having broad antibacterial activity specific...

2009-04-14

2011-11-29

Minnifield, Nita M (Department: 1645)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

Reexamination Certificate

active

08066990

ABSTRACT:
The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by SEQ. ID. NO: 2 which has no harm to human and animals comprising eukaryotic cells owing to its specificity to bacteria and has broad antibacterial activity, and a pharmaceutical composition for the prevention and treatment of infectious disease caused by bacteria comprising the said lysin protein as an active ingredient.

REFERENCES:
patent: 2009/0304638 (2009-12-01), Yoon et al.
Yoong et al. (J. Bacteriol., 186:4808-4812, 2004).
Fischetti (Int. J. Med. Microbiol., 300:357-362, 2010).
Son et al. (J. Appl. Microbiol., 108:1769-1779, 2010).
Borysowski, J.; Weber-Darbrowska, B., and Gárski, A. “Bacteriophage Endolysins as a Novel Class of Antibacterial Agents.”Exp. Biol. Med.231:366-377 (2006).

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