Refrigeration – Processes – Fractionally solidifying a constituent and separating the same
Reexamination Certificate
2005-08-23
2005-08-23
Doerrier, William C. (Department: 3744)
Refrigeration
Processes
Fractionally solidifying a constituent and separating the same
C062S541000, C034S288000, C210S808000, C210S768000
Reexamination Certificate
active
06931888
ABSTRACT:
A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
REFERENCES:
patent: 3673698 (1972-07-01), Guerard
patent: 5084187 (1992-01-01), Wilensky
patent: 5167838 (1992-12-01), Wilensky
patent: 5290827 (1994-03-01), Shine
patent: 5412027 (1995-05-01), Shine et al.
patent: 5494683 (1996-02-01), Liversidge et al.
patent: 5554382 (1996-09-01), Castor
patent: 5567769 (1996-10-01), Shine et al.
patent: 5639441 (1997-06-01), Sievers et al.
patent: 5727333 (1998-03-01), Folan
patent: 5750679 (1998-05-01), Haas et al.
patent: 5766637 (1998-06-01), Shine et al.
patent: 5776486 (1998-07-01), Castor et al.
patent: 5921478 (1999-07-01), Kamiwano et al.
patent: 5981474 (1999-11-01), Manning et al.
patent: 6063138 (2000-05-01), Hanna et al.
patent: 6095134 (2000-08-01), Sievers et al.
patent: 6214384 (2001-04-01), Pallado et al.
patent: 6228399 (2001-05-01), Parikh et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6284282 (2001-09-01), Maa et al.
patent: 6299906 (2001-10-01), Bausch et al.
patent: 6372260 (2002-04-01), Andersson et al.
patent: 6384090 (2002-05-01), Riede et al.
patent: 6387409 (2002-05-01), Khan et al.
patent: 6391452 (2002-05-01), Antonsen et al.
patent: 6414050 (2002-07-01), Howdle et al.
patent: 6416742 (2002-07-01), Stefely et al.
patent: 6440337 (2002-08-01), Hanna et al.
patent: 6670402 (2003-12-01), Lee et al.
patent: 2002/0010982 (2002-01-01), Hanna et al.
patent: 2002/0094318 (2002-07-01), Lee et al.
patent: 2003/0026844 (2003-02-01), Lee et al.
patent: 2003/0041602 (2003-03-01), Williams, III et al.
patent: 2003/0215515 (2003-11-01), Truong-Le et al.
patent: 01-158042 (1989-06-01), None
Sjostrom, Brita and Bergenstahl, Bjorn. Preparation of submicron drug particles in lecithin-stabilized o/w emulsions; I. Model studies of the precipitation of cholesteryl acetate, International Journal of Pharmaceutics 88 53-62 (1992) Elsevier Science Publishers B.V.
Sjostrom, Brita and Bergenstahl, Bjorn. Preparation of submicron drug particles in lecithin-stabilized o/w emulsions; I. Model studies of the precipitation of cholesteryl acetate, International Journal of Pharmaceutics 84 107-116 (1992) Elsevier Science Publishers B.V.
Yoshinobu, Kawano; Shiomori, Koichiro; Kiyoyama, Shiro; Takeshita, Koichiro; and Hatate, Yasuo. Characteristics of Biodegradable Microcapsules by Solvent Evaporation in (W/O/W) Emulsion System Journal of Chemical Engineering of Japan vol. 34.
Nakajima, Akira; Hashimoto, Kazuhito; and Watanabe, Toshiya. Recent Studies on Super-Hydrophobic Films, Monatshefte fur Chemie 132, 31-41 (2001). Austria.
Chung, Tze-Wen; Huang, Yi-You; and Liu Yi-Ze. Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres, International Journal of Pharmaceutics 212 161-169 (2001).
Chattopadhyay Pratibhash
Seitzinger Jeffrey S.
Shekunov Boris Y.
Doerrier William C.
Ferro Corporation
Rankin, Hill Porter & Clark LLP
LandOfFree
Lyophilization method and apparatus for producing particles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lyophilization method and apparatus for producing particles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lyophilization method and apparatus for producing particles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3495402