Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Fat or oil is basic ingredient other than butter in emulsion...
Patent
1997-09-25
1999-11-09
Mosley, Terressa
Food or edible material: processes, compositions, and products
Products per se, or processes of preparing or treating...
Fat or oil is basic ingredient other than butter in emulsion...
426601, 426531, 426583, 426656, 426688, A23D 700
Patent
active
059809701
DESCRIPTION:
BRIEF SUMMARY
The invention relates to lotions having a content of derivatives of unsaturated fatty acids.
Lotions offer the advantage over other topical formulations that they are easier to apply and to distribute, especially when used over large areas, and are absorbed into the skin better than creams or ointments. This applies in particular to lotions of the W/O type. From the type of emulsion, they are suitable for dry states of the skin. The bioavailability of incorporated substances is furthermore usually better than that from anhydrous topical formulations, and often also better than that from O/W lotions.
However, W/O lotions are difficult to stabilize. In the presence of relatively large proportions of esters of higher fatty acids, they tend to separate into the fatty phase and aqueous phase during storage.
Furthermore, if unsaturated fatty acid derivatives with one or more double bonds are employed in such lotions, there is a higher sensitivity to oxidation than when they are incorporated into anhydrous topical formulations.
W/O lotions having a high content of unsaturated fatty acids or derivatives thereof and good use properties which both are stable pharmaceutically and are also largely insensitive to oxidative influences during storage can be realized only with difficulty. This applies above all in the case of relatively high contents of these fatty acids or derivatives thereof.
Lotions in which the unsaturated fatty acids are subject to a relatively high oxidation effect are unsuitable for topical use. This is especially the case when used on already damaged and diseased skin, as is the case, for example, with atopy and psoriasis patients. Even with dry states of the skin, however, the oxidation decomposition products, such as peroxides, aldehydes and ketones, have an adverse effect and destroy the benefit of such preparations. The oxidative influence of sunlight manifests itself in particular.
The object of the invention was to provide water-in-oil lotions (W/O type) which are stable and in which at the same time the unsaturated fatty acids are not subject, or are subject to only a minor, non-troublesome extent, to harmful oxidative degradation.
The object of the invention has been achieved in that W/O emulsifiers and combinations with other emulsion constituents have been found which both stabilized the lotion in the presence of high proportions of unsaturated fatty acids or derivatives thereof and kept the unsaturated fatty acids stable to oxidation.
The invention relates to W/O lotions having a content of at least one unsaturated fatty acid derivative, which are characterized in that they comprise W/O emulsifiers, W/O stabilizers and/or W/O emulsion systems chosen from the group consisting of stabilizer (B2) based on a polyalkylene glycol copolymer and either (B), or being used, where, in each case, (3), and water and, if appropriate, additives or auxiliaries.
The W/O emulsifier (A) used is preferably an ethoxylated hydrogenated castor oil which contains, in particular, seven ethylene oxide units. Such products are obtainable, for example, under the CTFA designation "PEG-7 hydrogenated castor oil" and under the trade name "Cremophor WO 7" (BASF, DE) or the name "Arlacel 989" (Atlas Chemie, ICI, DE).
W/O emulsifiers (B1) which are preferably used are polyethylene or polypropylene glycol-1 glycerol. sorbitan isostearates, or else products known under the CTFA-designation "sorbitan isostearate+PEG-2 hydrogenated castor oil+ozocerite+hydrogenated castor oil". A commercial product known under the-name "Arlacel 582" (Atlas Chemie, ICI, DE) is particularly suitable.
The preferred W/O stabilizer (B2) is a polyethylene glycol/dodecyl glycol copolymer having, in particular, 45 ethylene glycol units. Such stabilizers are also known under the CTFA designation "PEG-45/dodecyl glycol copolymer". A product marketed under the trade name "Elfacos ST 9" (Akzo Chemie GmbH, DE) is preferred.
The preferred W/O emulsion system (C) is a methoxy/polyethylene/dodecyl glycol copolymer, having, in particular, 22 ethylene glycol
REFERENCES:
patent: 3658555 (1972-04-01), Menz et al.
patent: 4992293 (1991-02-01), Klemann et al.
patent: 5093142 (1992-03-01), Klemann et al.
patent: 5413804 (1995-05-01), Rhodes
Sattler Henning
Zelle Dagmar
Beiersdorf AG
Mosley Terressa
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