Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1995-06-06
1997-10-14
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424450, 424 94, A61K 9127
Patent
active
056769288
ABSTRACT:
The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
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patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4863717 (1989-09-01), Keana
patent: 4900540 (1990-02-01), Ryan
Chem. Pharm. Bull. 39(4) pp. 1018-1022(1991), vol. 39 No. 4, Possibility of Heat Sterilization of Liposomes, H. Kikuchi, A. Carlsson, K. Yachi and S. Hirota.
Berg Arne
Ege Thorfinn
Jacobsen Trond Vegard
Kikuchi Hiroshi
Klaveness Jo
Daiichi Pharmaceutical Co. Ltd.
Kishore Gollamudi S.
Nycomed Imaging AS
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