Lipoprotein associated phospholipase A2, inhibitors thereof and

Details Lipoprotein associated phospholipase A2, inhibitors thereof and Lipoprotein associated phospholipase A2, inhibitors thereof and

1995-11-14

1999-10-19

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 691, 4353201, 435325, 536 231, C12Q 168, C12P 2106, C12N 1500, C12N 506

Patent

active

059688181

ABSTRACT:
The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

REFERENCES:
patent: 5532152 (1996-07-01), Cousens et al.
U.T. Kim, et al., "Synthesis of Phospholipid Headgroups via Nucleophilic Ring Opening of 1.3.2-Dioxaphospholanes", J. Chem. Soc., Chem. Commun., pp. 70-71 (1993).
N. S. Chandrakumar. et al., "Stereospecific Synthesis of Ether Phospholipids. Preparation of 1-Alkyl-2-(acylamino)-2-deoxyglycerophosphorylcholines", J. Org. Chem, p. 1197-1202 (1983).
M.M. Ponpipom, et al., "Synthesis of Azide and Amide Analogs of Platelet-Activating Factor and Related Derivatives", Chem Phys Lipids, 35, pp. 29-37 (1984).
San, H. et al., Safety and Short Term Toxicity of a Novel and Cationic Formulation for Human Gene Therapy, Human Gene Therapy, 781-788, Dec. 1993.
Christoffersen, R. et al., Ribozymes as Human Therapeutic Agents, Journal of Medicinal Chemistry, 2023-2037, Nov. 1994.
Stull, R. et al., Antigene Ribozyme, and Aptomer Nucleic Acid Drugs: Progress and Prospects, Pharmaceuticals Research, 1995.

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