DNA encoding serotonin receptors

Details DNA encoding serotonin receptors DNA encoding serotonin receptors

1993-03-15

1999-10-19

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 235, 435 691, 4353201, C12N 1512

Patent

active

059688173

ABSTRACT:
The present invention describes nucleic acid molecules encoding human serotonin receptors, recombinant serotonin receptor proteins, cultured cells expressing recombinant serotonin receptor proteins, antibodies immunoreactive with serotonin receptor proteins, polypeptide serotonin receptor antagonists, oligonucleotide probes used for detecting nucleic acids which encode a human serotonin receptor, and nonhuman transgenic animals which express recombinant human serotonin receptor. Also disclosed are methods for screening for ligand binding to the described serotonin receptors and for serotonin receptor agonists and antagonists, for detection of serotonin receptors in tissues, and for therapeutic treatments involving the described human serotonin receptors.

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