Lipo-phosphoramidites

Details Lipo-phosphoramidites Lipo-phosphoramidites

1990-09-07

1995-05-30

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558157, 558169, 558168, 558180, 552104, 536 253, 536 2534, C07F 924

Patent

active

054203309

ABSTRACT:
Ether variant lipids bound to phosphoramidites are disclosed. These can be used to create oligonucleotides that are linked to stable lipid-like units. For example, dialkyl glycerols are linked to phosphoramidites.

REFERENCES:
patent: 4914210 (1990-04-01), Levinson et al.
Letsinger et al. Proc. Natl. Acad. Sci. USA, vol. 86, pp. 6553-6556, Sep. 1989.
S. Horvath et al., 154 Meth. In Enzym. 314-326 (1987).
J. Coull et al., 27 Tetr. Let. 3991-3994 (1986).
R. Shea et al., 18 Nuc. Acids Res. 3777-3783 (1990).
A. Kabanov et al., 259 Febs Let. 327-330 (1990).
F. Eckstein, 54 Ann. Rev. Biochem. 367-402 (1985).
B. Uznanski et al., 26 Chem. Scripta 221-224 (1985).
P. Miller et al., 25 Biochem. 5092-5097 (1986).
E. Stirchak et al., 52 J. Org. Chem. 4202-4206 (1987).
J. Haralambidis et al., 28 Tetr. Let. 5199-5202 (1987).
R. Letsinger et al., 110 J. Am. Chem. Soc. 4470-4471 (1988).
F. Seela et al., 71 Hel. Chem. Acta 1813-1823 (1988).
J. Habener et al., 85 P.N.A.S. 1735-1739 (1988).
M. Urdea et al., 16 Nucl. Acids Res. 4937-4956 (1988).

Affiliated with

Also associated with

Rating

Lipo-phosphoramidites does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipo-phosphoramidites, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipo-phosphoramidites will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-363583