Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents

Details Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents

1987-11-13

1988-11-29

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514216, 514222, 514230, 514252, 514253, 514318, 514321, 514326, 514333, 514336, 514338, 514343, 514422, 514427, 514438, 514444, 514445, 540480, 540582, 540596, 540597, 544 586, 544 587, 544131, 544146, 544360, 544364, 544377, 544379, 546194, 546197, 546213, 546256, 546270, 546281, 546284, 548526, 548527, 549 65, 549 77, A61K 3155, A61K 3138, C07D40906, C07D40914

Patent

active

047881844

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.

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Brittain, R. et al., Tips, Nov. 1981, pp. 310-313.

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