Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1996-06-07
1997-12-23
Naff, David M.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
435236, 424450, 424DIG14, 427 23, C12N 706, A61L 1548
Patent
active
057006792
ABSTRACT:
A novel formulation having anti-viral and spermicidal properties has been developed. The formulation contains lipid vesicles having an outer bilayer formed of a non-ionic amphiphile, a surfactant such as having spermicidal and/or anti-viral activity, an oil and a sterol. The selection of the components making the vesicle is such that the formulation provides rapid spermicidal or anti-viral activity. The formulation and methods of the invention are particularly useful in the mucous membranes such as the vaginal tract and has been tested against viruses such as HIV and Vaccinia.
REFERENCES:
patent: 2541103 (1951-02-01), Sander
patent: 4507281 (1985-03-01), Asculai et al.
patent: 4551148 (1985-11-01), Riley, Jr. et al.
patent: 5182104 (1993-01-01), Marcus et al.
patent: 5260065 (1993-11-01), Mathur et al.
patent: 5357636 (1994-10-01), Dresdner, Jr. et al.
patent: 5370876 (1994-12-01), Noll et al.
patent: 5439685 (1995-08-01), Augros
The Merck Index, Tenth Edition, Merck & Co., Inc, Rahway, NJ, p. 6522, 1983.
Buttar, H.S. et al., "Evaluation of the Cytotoxicity and Genotoxicity of the Spermicides Nonoxynol-9 and Octoxynol-9," Toxicology Letters, vol. 31, 65-73 (1986).
Excerpt from The Merck Index: An Encyclopedia of Chemicals and Drugs, 9th Edition, published by Merck and Co., Inc., Rahway, N.J., 6487 (1976).
Groves, M.J. et al., "A Note on the Interaction Between Two Phosphated Surfactants," J. Pharm. Pharmac., vol. 26, 624-628 (1974).
Groves, M.J. et al., "Phase Studies of Mixed Phosphated Surfactants, n-hexane and Water," J. Pharm. Pharmac., vol. 26, 616-623 (1974).
Sunamoto, J. et al., "Liposomal Membranes. XIX. Interaction Between Spermicidal Agents and Liposomes Reconstituted with Boar Spermatozoal Lipids," Chem. Pharm. Bull., vol. 32, No. 8, 2891-2897 (1984).
Sunamoto, J. et al., "Liposomal Membranes. XVIII. Interaction of Spermicidal Agents with Liposomal Membranes," Chem. Pharm. Bull., vol. 31, No. 12, 4230-4235 (1983).
Tryphonas, L. and Buttar, H.S., "Effects of the Spermicide Nonoxynol-9 on the Pregnant Uterus and the Conceptus of Rat," Toxicology, vol. 39, 177-186 (1986).
Kerr Janet M.
Naff David M.
Novavax Inc.
LandOfFree
Lipid vesicles having a bilayer containing a surfactant with ant does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipid vesicles having a bilayer containing a surfactant with ant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid vesicles having a bilayer containing a surfactant with ant will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1802003