Lipid remodeling of GPI-anchored proteins

Details Lipid remodeling of GPI-anchored proteins Lipid remodeling of GPI-anchored proteins

2007-08-07

2010-06-22

Fronda, Christian L (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07741087

ABSTRACT:
This invention provides proteins and genes thereof involved in the GPI lipid remodeling process and, thereby and constructing a system for screening for useful substances such as anticancer agents and a system for detecting abnormalities in the GPI lipid remodeling process.

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Morihisa Fujita et al., “Inositol Deacylation by Bst1p Is Required for the Quality Control of Glycosylphosphatidylinositol-anchored Proteins” Molecular Biology of the Cell, vol. 17, Feb. 2006, pp. 834-850.
Regine Bossom et al., “GUP1 ofSaccharomyces cerevisiaeEncodes an O-Acyltransferase Involved in Remodeling of the GPI Anchor”, Molecular Biology of the Cell, vol. 17, 2636-2645, Jun. 2006.
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