Leukotriene A4 hydrolase from candida albicans

Details Leukotriene A4 hydrolase from candida albicans Leukotriene A4 hydrolase from candida albicans

1994-11-01

1996-06-25

Patterson, Jr., Charles

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 43525422, 4353201, 536 232, C12N 914, C12N 1555

Patent

active

055299164

ABSTRACT:
The invention relates to yeast leukotriene A.sub.4 hydrolase enzymes and nucleic acids.

REFERENCES:
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Medina, J. F., et al., "Molecular Cloning and Expression of Mouse Leukotriene A.sub.4 Hydrolase cDNA", Biochemical and Biophysical Research Communications, 176(3):1516-1524 (1991).
Makita, N., et al., "Molecular cloning and functional expression of rat leukotriene A.sub.4 hydrolase using the polymerase chain reaction", FEBS Letters, 299(3):273-277 (1992).
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Claesson, H-E., et al., "Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukortiene A.sub.4 into leukotrienes B.sub.4, C.sub.4, D.sub.4 and E.sub.4 ", (1988), Env. J. Biochem 123(1), 93-100.
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Wetterholm, A., et al., "Recombinant mouse leukotriene A.sub.4, hydrolase: a zinc metalloenzyme with dual enzymatic activities", Biochemical and Biophysical Research Communications, pp. 96-102 (1991), vol. 1082(2).
Brasch, J., et al., "Candida albicans in Glucose-free Media Contains Serum-independent Chemotactic Activity", Acta Derm Venerol (Stockh), 72:1-3 (1992).
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McGee, J. E., et al., "Erythrocyte-neutrophil interactions: Formation of leukotriene B.sub.4 by transcellular biosynthesis", Proc. Natl. Acad. Sci. USA, 83:1349-1353 (1986).
Castro, M., et al., "Candida albicans Stimulates Arachidonic Acid Liberation from Alveolar Macrophages through .alpha.-Mannan and .beta.-Glucan Cell Wall Components", Infection and Immunity, 62(8):3138-3145 (1994).
Parker, C. W., "Lipid Mediators Produced Through the Lipoxygenase Pathway", Ann. Rev. Immuno., pp. 65-84 (1987).
Haeggstrom, J., "Cytosolic Liver Enzymes Catalyzing Hydrolysis of Leukotriene A.sub.4 to Leukotriene B.sub.4 and 5,6-Dihydroxyeicosatetraenoic Acid", Methods in Enzymology, 187:324-334 (1990).

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