Leucyl tRNA synthetase from Streptococcus pneumoniae

Details Leucyl tRNA synthetase from Streptococcus pneumoniae Leucyl tRNA synthetase from Streptococcus pneumoniae

1998-02-03

2000-04-11

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, 536 232, C12N 900, C12N 1500, C12Q 168, C07H 2104

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active

06048716&

ABSTRACT:
The invention provides leuS polypeptides and DNA (RNA) encoding leuS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing leuS polypeptides to screen for antibacterial compounds.

REFERENCES:
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Fleischmann et al., "Whole-genome random sequencing andassemblyof Haemophilus influenzae Rd.," Science, 269 p. 496-512 (1995).
Dissertation Abstracts International, vol. 45, No. 6B, 1984 p. 1673, Dana, S.L.S. "Genetic mapping and molecular cloning of specific genes using interspecific human-chinese hamster cell hybrids (chromosome-5, leucyl transfer-RNA synthetase)".
Dissertation Abstracts International, vol. 45, No. 3B, 1983 p. 772, Chang S.M.W. Genetic and biochemical studies of aminoacyl-transfer-RNA synthetase mutants and their revertants inchinese hamster lung cells.
Vander Horn et al., "Cloning and nucleotide sequence of the leucyl-tRNA synthetase geneof Bacillus subtilis," J. of Bacteriology, 174(12) p. 3298-3935 (1992).
Vinella et al., "Penicillin-binding protein 2 inactivation in Escherichia coli results in cell deivision inhibition, which is relieved by FtsZ overexpression," J. of Bacteriology, 175(20) p. 6704-6710 (1993).
Hartlein et al., "Molecular cloning and nucleotide sequence of the gene for Escherichia voli leucyl-tRNA synthetase," Nucleic Acids Research, 15(4) p. 10199-10210 (1987).

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