lep

Details lep lep

1996-11-25

1998-07-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 4352523, 43525233, 4353201, 435885, 536 232, C12N 952, C12N 950, C12N 120, C07H 2104

Patent

active

057861978

ABSTRACT:
lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the treatment of infection, particularly bacterial infections. Antagonists against such lep and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of lep nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding leader peptidase and for detecting the polypeptide in a host.

REFERENCES:
Meijer, W., et al. The endogenous Bacillus subtilis (natto) plasmids pTA1015 and pTA1040 contain signal peptidase-encoding genes: identification of a new structural module on cryptic plasmids. Molecular Microbiology (1995) 17(4), 621-631.
Swiss-Prot: P41027 located on the internet. World Wide Web server Amos Bairoch, Medical Biochemistry Department Centre, Medical Universitaire 1, Rue Michele Servet, 1211 Geneva 4, Switzerland. (1995).

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