Least-square deconvolution (LSD): a method to resolve DNA...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C702S020000, C707S793000, C435S006120

Reexamination Certificate

active

10265908

ABSTRACT:
Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.

REFERENCES:
patent: 5161204 (1992-11-01), Hutcheson et al.
patent: 5273632 (1993-12-01), Stockham et al.
patent: 5374527 (1994-12-01), Grossman
patent: 5470710 (1995-11-01), Weiss et al.
patent: 5541067 (1996-07-01), Perlin
patent: 5580728 (1996-12-01), Perlin
patent: 5759369 (1998-06-01), Menchen et al.
patent: 5876933 (1999-03-01), Perlin
patent: 6054268 (2000-04-01), Perlin
patent: 6741983 (2004-05-01), Birdwell et al.
patent: 6750011 (2004-06-01), Perlin
patent: 6807490 (2004-10-01), Perlin
patent: 2002/0086289 (2002-07-01), Straus
patent: 2002/0152035 (2002-10-01), Perlin
patent: 2003/0143554 (2003-07-01), Berres et al.
Perlin, Mark W., et al., “Linear Mixture Analysis: A Mathematical Approach to Resolving Mixed DNA Samples”, J Forensic Sci 2001, vol. 46 No. 6, pp. 1372-1378.
Perlin, Mark W., J Forensic Sci, Sep. 2002, vol. 47, No. 5, Paper ID JFS2002123—475.
Wang, Tse-wei, J Forensic Sci, Sep. 2002, vol. 47, No. 5, Paper ID JFS20002092—475, published Aug. 21, 2002.
Schwartz et al., “Flourescent Multiplex linkage analysis and carrier detection for Duchenne/Becker Muscular Dystrophy”, Am. J. Human Genetics 51:721-729, 1992.
McConkey, E.H., Human Genetics, The Molecular Revolution Jones and Bartlett Publishers, 1993, pp. 92-112.
Clayton et al., “Analysis and interpretation of Mixed Forensic Stains Using DNA STR Profiling”, Forensic Science International, vol. 91 pp. 55-70 (1998).
Gill et al. , Interpreting Simple STR Mixtures using Allele Peak Areas, 1998, Forensic Science International, vol. 91 pp. 41-53.
Evett et al., Taking Account of Peak Areas when Interpreting Mixed DNA Profiles, 1998, Journal of Forensic Sciences, vol. 43., No. 1, pp. 62-69.
Perlin et al., Toward Fully Automated Genotyping: Genotyping Microsatellite Markers by Deconvolution, 1995, AMerican Journal of Human Genet., vol. 57, pp. 1199-1210.
Wang, T. and Xue, N. “Mixture STR/DNA Deconvolution Using Allele Peak Area Data and the Least Square Technique,”12thInternational Symposium on Human Identification, Biloxi, MS, Oct. 9-12, 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Least-square deconvolution (LSD): a method to resolve DNA... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Least-square deconvolution (LSD): a method to resolve DNA..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Least-square deconvolution (LSD): a method to resolve DNA... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3756049

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.