Lactams and uses thereof

Details Lactams and uses thereof Lactams and uses thereof

2007-11-13

2007-11-13

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S211060, C514S212030, C514S212070, C540S488000, C540S491000, C540S523000, C540S527000

Reexamination Certificate

active

10528640

ABSTRACT:
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.

REFERENCES:
patent: WO98/28268 (1998-07-01), None
patent: WO9967220 (1999-12-01), None
patent: WO 0172324 (2001-10-01), None
Banzatti et al., “Synthesis of phenyl-substituted 2H-3,4-dihydro-3-aminomethyl-1,4-benzoxazines. Intermediates for 1H-2,3,3a,4-Tetrahydroimidazo-[5,1-c][1,4]benzoxizan-1-one derivatives. Part II,”J. Heterocyclic Chem. (1983) 20:259-265.
Karim et al., “Synthese d'aminophosphinephosphinites chiraux. Utilisation en reduction asymetrique catalytique,”J. Organometallic Chem. (1986) 317(1):93-104.
Lu et al., “Process development on the preparation oftrans-(+)-2-methylaminocyclohexanol: a fascinating resolution example,”Org. Proc. R&D(2001) 5:184-185.
Remington's Pharmaceutical Sciences, 17thed., Mack Publishing Company, Easton, PA 1985, p. 1418-1419.

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