Lactam-containing hydroxamic acids

Details Lactam-containing hydroxamic acids Lactam-containing hydroxamic acids

1995-03-21

1997-09-30

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540528, 546243, 548550, 514327, 514424, C07D22310, A61K 3155

Patent

active

056725981

ABSTRACT:
The present invention relates to compounds that exhibit inhibitory activity against matrix metalloproteases ("MMPs"). Because MMPs are known to play a role in tissue degradation, the compounds of the present invention may be useful in preventing or treating diseases associated with excess MMP activity. In particular, the compounds have a structure according to Formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are various substituents as described in the specification; and Q is an alkyl chain, an alkenyl chain, a heteroalkyl chain, or a heteroalkenyl chain, wherein said chain has 2, 3, or 4 chain atoms and is unsubstituted or substituted with one or more alkyl moieties; or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, acyloxyamide, or imide thereof. Preferred are those compounds where Q is an alkyl chain having 2, 3 or 4 chain atoms.
The invention also relates to pharmaceutical compositions comprising these compounds, and methods for preventing or treating diseases associated with unwanted MMP activity using the compounds and compositions.

REFERENCES:
patent: 4743587 (1988-05-01), Dickens et al.
patent: 4771038 (1988-09-01), Wolanin et al.
patent: 4918105 (1990-04-01), Cartwright et al.
patent: 4996358 (1991-02-01), Handa et al.
patent: 5075302 (1991-12-01), Neustadt
patent: 5183900 (1993-02-01), Galardy et al.
patent: 5189178 (1993-02-01), Galardy et al.
patent: 5300674 (1994-04-01), Crimmin et al.
patent: 5310763 (1994-05-01), Campion et al.
patent: 5453438 (1995-09-01), Campion et al.
Johnson, W.H., N.A. Roberts and N. Borkakoti, "Collagenase Inhibitors: Their Design and Potential Therapeutic Use", J. Enzyme Inhibition, vol. 2, pp. 1-22, (No Month Identified 1987).
Odake, Sh., T. Okayama, M. Obata, T. Morikawa, S. Hattori, H. Hori and Y. Nagai, "Vertebrate Collagenase Inhibitor. II. Tetrapeptidyl Hydroxamic Acids", Chem. Pharm. Bull., vol. 39, No. 6, pp. 1489-1494 (Jun. 1991).

Affiliated with

Also associated with

Rating

Lactam-containing hydroxamic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lactam-containing hydroxamic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lactam-containing hydroxamic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2256763