Labeled resiniferatoxin derivatives

Details Labeled resiniferatoxin derivatives Labeled resiniferatoxin derivatives

2006-09-26

2006-09-26

Trinh, Ba K. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S349000

Reexamination Certificate

active

07112685

ABSTRACT:
This invention relates resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof.

REFERENCES:
patent: 5232684 (1993-08-01), Blumberg et al.
patent: WO 98/20867 (1998-05-01), None
patent: WO 9/09140 (1999-02-01), None
S. Bevan and J. Szolcsanyi , Sensory neuron-specific actions of capsaicin: mechanisms and applications, Trends Pharmacol Sci, Aug. 1990 vol. 11 pp. 330-333.
J. Szolcsanyi, Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: facts and scopes of an unorthodox neuroregulatory mechanism, Progress in Brain Research, 1996, vol. 113, pp. 343-359.
Szolcsanyi et al., Resiniferatoxin: An Ultrapotent Neurotoxin of Capsaicin-sensitive Primary Afferent Neurons, Annals of the New York Academy of Sciences, 1991 vol. 632, pp. 473-475.
Veronesi et al., Particulate Matter initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acis Receptors in a Human Bronchial Epithlial Cell Line, Toxicology and Applied Pharmacology 154, (1999) pp. 106-115.
Winter J et al, Capsaicin and pain mechanisms, British Journal of Anaesthesia 1995: 75: 157-168.
Caterina MJ, et al., The capsaicin receptor: a heat-activated ion channel in the pain pathway, Nature, vol. 389 Oct. 1997, pp. 816-824.
Tominaga M et al., The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli, Neuron, vol. 21, pp. 531-543 Sep. 1998.
Wood JN et al., Capsaicin-Induced Ion Fluxes in Dorsal Root Ganglion Cells in Culture, The Journal of Neuroscience, Sep. 1988, 8(9): 3208-3220.
Bevan S. et al., Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin, Br. J Pharmacol, (1992), 107, pp. 544-552.
Harvey, JS et al., Activation of Protein Kinase C by the Capsaicin Analogue Resiniferatoxin in Sensory Neurones, Journal of Neurochemistry 65: 1995 1309-1317.
Szallasi, Goso et al, Competitive Inhibition by Capsazepine of [3H]Resiniferatoxin Binding to Central (Spinal Cord and Dorsal Root Ganglia) and Peripheral (Urinary Bladder and Airways) Vanilloid (Capsaicin) Receptors in the Rat, J Pharmacol Exp Ther, 267: 728-33 1993.
Szallasi & Goso, Characterization by [3H]resiniferatoxin binding of a human vanilloid (capsaicin) receptor in post-mortem spinal cord, Neuroscience Letters, 165(1994) 101-104.
Szallasi A & Blumber PM, Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes, Brain Research, 524, (1990) 106-111.
ACS, M Palkovits, Blumberg, [3H]Resiniferatoxin binding by the human vanilloid (capsaicin) receptor, Molecular Brain Research, 23: 185-90, 1994.
Blumberg et al., Labelled Resiniferatoxin, Compositions Thereof, and Methods for Using the Same., Filed Jun. 29, 1990, National Institute of Health, Bethesda, MD, Report Nos: PAT-APPL-7-546 141 48pages.
Andil et al., “A practical and Cost-Effective Synthesis of 6,7-Dimethoxy-2-tetralone”, SYNTHESIS, vol. 12, 1999, pp. 2033-2035, XP002208174.
Walpole et al., “Similarities and Differences in the SAR's of Capsaicin and Resininferatoxin Analogues”, J.Med.Chem., vol. 39, 1996, pp. 2939-2952, XP002208173, Xcheme 4, 5thtransformation (coupling with DCCI and DMAP).

Affiliated with

Also associated with

Rating

Labeled resiniferatoxin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labeled resiniferatoxin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labeled resiniferatoxin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3588096