L-.alpha.-amino acids as transdermal penetration enhancers

Details L-.alpha.-amino acids as transdermal penetration enhancers L-.alpha.-amino acids as transdermal penetration enhancers

1985-07-12

1988-03-22

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514171, 514179, 514561, 514843, 514947, A61K 3156

Patent

active

047328924

ABSTRACT:
The disclosed invention provides methods and compositions ulilizing L-.alpha.-amino acids for enhancing the rate of penetration through the skin of both topical medicaments and of drugs employed for systemic administration. Fifteen L-.alpha.-amino acids were tested and found to enhance the rate of penetration of levonorgestrel through hairless mouse skin. These were Tryptophan, Glutamic Acid, Glycine, Proline, Alanine, Serine, Arginine, Aspartic Acid, Leucine, Isoleucine, Cysteine, Valine, .alpha.-Aminobutyric Acid, Norvaline and Norleucine. The effect of pH on the rate of penetration of the various amino acids was also examined and found to be unpredictable overall.

REFERENCES:
patent: 3527864 (1970-09-01), Kilmer et al.
patent: 3787571 (1974-01-01), Higuchi
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 4258037 (1981-03-01), Juvin
patent: 4362737 (1982-12-01), Schafer et al.
patent: 4409233 (1983-10-01), Tsukada et al.
patent: 4537776 (1985-08-01), Cooper

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