L-683,590 microbial transformation product

Details L-683,590 microbial transformation product L-683,590 microbial transformation product

1991-03-05

1992-08-11

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540452, A61K 31395, A61K 31695, C07D49816, C07F514291

Patent

active

051380528

ABSTRACT:
Described is a new L-679,934 (FK-506) antagonist, L-686,292, a C-15, C-31 bisdemethylated, derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide reverses the immunosuppressant action of L-679,934 (FK-506), and can be used diagnostically as a tool to determine the presence of FK-506 macrolide type immunosuppressants in natural product broths, distinguishing such immunosuppressants from other chemical families such as the cycloporins.

REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4894366 (1990-01-01), Okuhara et al.
J. Antibiotics, A15, pp. 231-241 by Arai, et al., contains an infrared spectrum of ascomycin.

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