Microbial transformation process for antihypertensive products

Details Microbial transformation process for antihypertensive products Microbial transformation process for antihypertensive products

1991-02-25

1992-02-04

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 85, 435121, 435886, C12P 1718, C12P 1710, C12N 100

Patent

active

050859927

ABSTRACT:
Fermentation of the microorganism Streptomyces sp. MA6751 (ATCC No. 55043) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields an N2-tetrazole .beta.-glucuronide analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

REFERENCES:
patent: 4404281 (1983-09-01), O'Connor et al.
patent: 4840898 (1989-06-01), Lievense et al.
patent: 4880804 (1989-11-01), Carini et al.
Kieslich, K. Microbial Transformations of Non-Steroid Cyclic Compounds. Germany, George Verlag, 1976, pp. 245 and 1206.

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